Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19

Loukman Omarjee (1, 2, 3) , Frédérique Perrot , Olivier Meilhac (4, 5) , Guillaume Mahe (1) , Guilhem Bousquet (6, 7) , Anne Janin (7)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 NuMeCan - Nutrition, Métabolismes et Cancer
3 CIC - Centre d'Investigation Clinique [Rennes]
4 DéTROI - Diabète athérothrombose et thérapies Réunion Océan Indien
5 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
6 Hôpital Avicenne [AP-HP]
7 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress

Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.

Mots clés: COVID-19; immunometabolism; immunosenescence; inflammaging; rapamycin-metformin-dimethyl fumarate

Domaines: Sciences du Vivant [q-bio]

Loukman Omarjee, Frédérique Perrot, Olivier Meilhac, Guillaume Mahe, Guilhem Bousquet, et al.. Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19. Aging, 2020, 12 (24), pp.26263—26278. ⟨10.18632/aging.202422⟩. ⟨hal-03102052⟩