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Prenatal maternal stress is associated with behavioural and epigenetic changes in Japanese quail

Abstract : Prenatal maternal stress (PMS) influences many facets of offspring’s phenotype including morphology, behaviour and cognitive abilities. Recent research suggested that PMS also induced epigenetic modifications. In the present study, we analysed, in the Japanese quail, the effects of PMS on the emotional reactivity and cognitive abilities of the F1 offspring. We also investigated in the hippocampus, the paraventricular hypothalamic nucleus and subnuclei of the arcopallium/amygdala the level of two histone post-translational modifications, H3K4me2 and H3K27me3, known to be impacted by stress. We found that PMS does not affect F1 quail’s learning abilities but increases their emotional reactivity. Moreover, we demonstrated that PMS induced an increased density of H3K27me3 positive cells, in the hippocampus, paraventricular hypothalamic nucleus and dorsal nucleus of the amygdala, but not variations of H3K4me2. As these brain regions are involved in the control of vertebrates’ emotional responses, the effect of PMS on the epigenetic mark H3K27me3 could possibly be a mechanism involved in the behavioural effects we observed in F1 quail.
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https://hal.archives-ouvertes.fr/hal-03555171
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, March 30, 2022 - 3:47:00 PM
Last modification on : Friday, July 22, 2022 - 3:33:45 PM

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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

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Marion Charrier, Sophie Lumineau, Marion Georgelin, Maryse Meurisse, Rupert Palme, et al.. Prenatal maternal stress is associated with behavioural and epigenetic changes in Japanese quail. Psychoneuroendocrinology, Elsevier, 2022, 137, pp.105661. ⟨10.1016/j.psyneuen.2022.105661⟩. ⟨hal-03555171⟩

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