Evaluating optimal strategies for electric field dosimetry from intracranial electrodes

Borja Mercadal (1) , Fabiola Alonso (2) , Denys Nikolayev (3) , Ricardo Salvador (4) , Julien Modolo (5) , Fabrice Bartolomei (6) , Fabrice Wendling (5) , Giulio Ruffini (1)

1 Neuroelectrics Barcelona
2 Department of Biomedical Engineering
3 IETR - Institut d'Électronique et des Technologies du numéRique
4 IBBE - Institute of Biophysics and Biomedical Engineering
5 LTSI - Laboratoire Traitement du Signal et de l'Image
6 TIMONE - Hôpital de la Timone [CHU - APHM]

Intracranial electrodes are used clinically for diagnostic (e.g. in drug-refractory epilepsy) or therapeutic (deep brain stimulation, e.g. epilepsy) purposes. Electrical stimulation delivered through such electrodes is key to understand how the resulting electric fields modulate neuronal (hyper)excitability. However, quantifying such fields in a patient-specific way is challenging, since etiology impacts brain anatomy (morphology) and biophysical properties (e.g., conductivity). Here, we evaluate how to approximate the electric fields from intracranial electrodes used clinically. Those results are the first step towards computationally tractable, patient-specific models of electric fields generated during neuromodulation protocols.

Mots clés: Dosimetry (computational); Static; Work in Progress Presented by: Borja Mercadal

Domaines: Electromagnétisme

Borja Mercadal, Fabiola Alonso, Denys Nikolayev, Ricardo Salvador, Julien Modolo, et al.. Evaluating optimal strategies for electric field dosimetry from intracranial electrodes. BioEM 2021, Sep 2021, Ghent, Belgium. ⟨hal-03388585⟩