Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors - Institut Génétique et Développement de Rennes Accéder directement au contenu
Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2022

Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors

Résumé

The lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes. By the end of embryogenesis the lymph gland is composed of a single pair of lobes. Two additional pairs of posterior lobes develop during larval development to contribute to the mature lymph gland. In this study we describe the ontogeny of lymph gland posterior lobes during larval development and identify the genetic basis of the process. By lineage tracing we show here that each posterior lobe originates from three embryonic pericardial cells, thus establishing a bivalent blood cell/nephrocyte potential for a subset of embryonic pericardial cells. The posterior lobes of L3 larvae posterior lobes are composed of heterogeneous blood progenitors and their diversity is progressively built during larval development. We further establish that in larvae, homeotic genes and the transcription factor Klf15 regulate the choice between blood cell and nephrocyte fates. Our data underline the sequential production of blood cell progenitors during larval development.
Fichier principal
Vignette du fichier
Identificationofbipotential.pdf (5.95 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03810377 , version 1 (14-03-2023)

Licence

Paternité

Identifiants

Citer

Ismaël Morin-Poulard, Manon Destalminil-Letourneau, Laetitia Bataillé, Jean-Louis Frendo, Gaëlle Lebreton, et al.. Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors. Frontiers in Cell and Developmental Biology, 2022, 10, pp.834720. ⟨10.3389/fcell.2022.834720⟩. ⟨hal-03810377⟩
45 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More