Skip to Main content Skip to Navigation
Journal articles

Fine Particulate Matter Related to Multiple Sclerosis Relapse in Young Patients

Abstract : Objective: Particulate matter (PM) of aerodynamic diameter smaller than 10 µm (PM 10) has been associated with multiple sclerosis (MS) relapse. However, the impact of smaller PM with a greater ability to penetrate human organism has never been assessed. We evaluated the impact of PM smaller than 2.5 µm (PM 2.5) on the risk of MS relapse. Material and Methods: In a case-crossover study, we included 2,109 consecutive hospitalizations likely due to MS relapse in day hospital in 5 MS centers in the Paris area from January 2009 to December 2013. For each hospitalization, the natural logarithm of the average weekly PM 2.5 concentrations (µg/m 3) at the patient's residence address during each of the 6 weeks (week[0] to week[−5]) preceding admission was compared with the concentration during the previous week, using a conditional logistic regression adjusted on temperature, flu-like syndrome rate, pollen count, and holiday period. Results: PM 2.5 average concentration during week[−3] was significantly associated with the risk of hospitalization for MS relapse [OR = 1.21 (CI 1.01;1.46)]. The association was stronger in patients younger than 30 years [OR=1.77 (CI 1.10; 2.83)]. Conclusion: Our study demonstrates an association between exposure to PM 2.5 and MS relapse, particularly in young people.
Document type :
Journal articles
Complete list of metadata
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Tuesday, June 8, 2021 - 4:08:12 PM
Last modification on : Monday, June 21, 2021 - 8:39:39 AM


Publication funded by an institution



Edouard Januel, Boris Dessimond, Augustin Colette, Isabella Annesi-Maesano, Bruno Stankoff. Fine Particulate Matter Related to Multiple Sclerosis Relapse in Young Patients. Frontiers in Neurology, Frontiers, 2021, 12, ⟨10.3389/fneur.2021.651084⟩. ⟨hal-03254149⟩



Record views


Files downloads