Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Suzanne Dufresne (1) , Cindy Richard (1) , Arthur Dieumegard (1) , Luz Orfila (1) , Gregory Delpon (2) , Sophie Chiavassa (2) , Brice Martin (1) , Laurent Rouvière (3) , Jean-Michel Escoffre (4) , Edward Oujagir (4) , Baudouin Denis de Senneville (5, 6) , Ayache Bouakaz (4) , Nathalie Rioux-Leclercq (7, 8) , Vincent Potiron (9, 10) , Amélie Rébillard (1, 11)

1 M2S - Laboratoire Mouvement Sport Santé
2 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
3 IRMAR - Institut de Recherche Mathématique de Rennes
4 iBraiN - Imaging, Brain & Neuropsychiatry
5 IMB - Institut de Mathématiques de Bordeaux
6 MONC - Modélisation Mathématique pour l'Oncologie
7 Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes]
8 Irset - Institut de recherche en santé, environnement et travail
9 LabCT - Laboratoire de Biologie des Cancers et de Théranostic
10 CRCINA-ÉQUIPE 9 - Apoptosis and Tumor Progression
11 IUF - Institut universitaire de France

Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels. Apparent microbubble transport was enhanced with VWR, which we hypothesized could improve the RT response. When repeating the experiments and adding RT, however, we observed that VWR did not influence RT efficiency. These findings contrasted with previous results and prompted us to evaluate if the lack of effects observed on tumor growth could be attributable to the physical activity modality used. Using PC-3 and PPC-1 xenografts, we randomized mice to either inactive controls, VWR, or treadmill running (TR). In both models, TR (but not VWR) slowed down tumor growth, suggesting that the anti-cancer effects of physical activity are dependent on its modalities. Providing a better understanding of which activity type should be recommended to cancer patients thus appears essential to improve treatment outcomes.

Mots clés: radiotherapy; prostate cancer; exercise; physical activity; radiation therapy; vascularization; proliferation

Domaines: Cancer

Suzanne Dufresne, Cindy Richard, Arthur Dieumegard, Luz Orfila, Gregory Delpon, et al.. Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?. Cancers, 2021, 13 (21), pp.5402. ⟨10.3390/cancers13215402⟩. ⟨inserm-03409985⟩