Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration

Astrid Bacle (1, 2) , Antoine Dupuis (1, 2) , Mohamed Belmouaz (2) , Marc Bauwens (2) , Guillaume Cambien (1, 2) , Nicolas Venisse (1, 2) , Pascale Pierre-Eugene , Sophie Potin (3, 4) , Virginie Migeot (1, 2) , Sarah Ayraud-Thevenot (1, 2)

1 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
2 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
3 Irset - Institut de recherche en santé, environnement et travail
4 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

The health safety conditions governing the practice of online hemodiafiltration (OL-HDF) do not yet incorporate the risks related to the presence of endocrine disruptors such as bisphenol A (BPA). The aim of this study was to assess, for the first time, the exposure to BPA but also to its chlorinated derivatives (ClxBPA) (100 times more estrogenic than BPA) during OL-HDF. We demonstrated that BPA is transmitted by the different medical devices used in OL-HDF: ultrafilters, dialysis concentrate cartridges (and not only dialyzers, as previously described). Moreover, BPA has been found in dialysis water as well as in ultrapure dialysate and replacement fluid due to contamination of water coming from municipal network. Indeed, due to contaminations provided by both ultrafilters and water, high levels of BPA were determined in the infused replacement fluid (1033 ng.L−1) from the beginning of the session. Thus, our results demonstrate that dialysis water must be considered as an important exposure source to endocrine disruptors, especially since other micropollutants such as ClxBPA have also been detected in dialysis fluids. While assessment of the impact of this exposure remains to be done, these new findings should be taken into account to assess exposure risks in end-stage renal disease patients

Mots clés: online hemodiafiltration; endocrine disruptors; hemodialysis; bisphenol A; chlorinated derivatives of bisphenol A; end-stage renal disease

Domaines: Urologie et Néphrologie; Toxicologie

Astrid Bacle, Antoine Dupuis, Mohamed Belmouaz, Marc Bauwens, Guillaume Cambien, et al.. Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration. Biomolecules, 2019, 9 (9), pp.E403. ⟨10.3390/biom9090403⟩. ⟨hal-02280772⟩