Synthesis, crystal structure study, and evaluation of antimicrobial and antibiofilm activities of a novel dihydroisoquinoline-derived
Résumé
Models of dihydroisoquinoline imine 2, oxaziridine 3 and nitrone 4 were synthesized and characterized through the mass spectrum, elemental analysis and NMR spectral studies. The crystal structure of compound 4 was determined from single crystal X-ray diffraction data. All these compounds were evaluated for their antimicrobial and antibiofilm activities, represented here with MICs values and% anti-adherence activity. Antimicrobial activity showed MICs values ranged between 0.31 and more than 2.5 mg/ml and Anti-adherence activity reached more than 75% especially with nitrone compound 4 when applied at a concentration of 0.312 mg/ml.
Domaines
Chimie
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Selmi et al - 2022 - Synthesis, crystal structure study, and evaluation of antimicrobial.pdf (1.15 Mo)
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Selmi_1-s2.0-S0022286021023103-mmc1.pdf (655.52 Ko)
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