Design of polyurea networks containing anticancer and anti-inflammatory drugs for dual drug delivery purposes - Chimie du Solide et Matériaux Accéder directement au contenu
Article Dans Une Revue Journal of Applied Polymer Science Année : 2022

Design of polyurea networks containing anticancer and anti-inflammatory drugs for dual drug delivery purposes

Résumé

Naproxen (Nap), a non-steroidal anti-inflammatory drug, and 5-fluorouracil (5FU), an anticancer drug, were easily incorporated into a polyurea xerogel. Polyureas (PUr) were synthesized by one pot reaction via sol-gel chemistry. Soft segments were based on polyetheramine-PEO and hard segments were based on a hexamethylene diisocyanate trimer (HDI). The final materials were characterized by Fourier transform infrared (FTIR) spectroscopy, small-angle X-ray scattering (SAXS), and differential scanning calorimetry (DSC). Polyurea can assume many forms revealing its versatility in terms of produced shapes. In good agreement with FTIR, SAXS studies showed a microphase separated structure arising from inter-hard-domain spacings, which remains unchanged after incorporation of the drugs. DSC analysis demonstrated that the PEO chain mobility was poorly affected after the drugs incorporation due to the solvation of the drugs through the network. The water uptake and the amount of drug released agree well, playing an important role for controlled Nap and 5FU release. This work opens positive perspectives for ocular drug delivery and wound management, due to the easy processability of the xerogel, which has high feasibility to be moldable as pharmaceutical devices for contact lenses and transdermal patches purposes containing distinct therapeutic agents.

Domaines

Chimie Polymères
Fichier principal
Vignette du fichier
Resende et al - 2021 - Design of polyurea networks containing anticancer and anti-inflammatory drugs.pdf (2.84 Mo) Télécharger le fichier
Resende_app51970-sup-0001-supinfo.pdf (424.79 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03512408 , version 1 (28-01-2022)

Identifiants

Citer

Mariane A. de Resende, Gabriele A. Pedroza, Lucia H. G. M. C. Macedo, Ricardo de Oliveira, Maria Amela-Cortes, et al.. Design of polyurea networks containing anticancer and anti-inflammatory drugs for dual drug delivery purposes. Journal of Applied Polymer Science, 2022, 139 (16), pp.51970. ⟨10.1002/app.51970⟩. ⟨hal-03512408⟩
56 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More