Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise

Omid Razi (1) , Bakhtyar Tartibian (2) , Ana Maria Teixeira (3) , Nastaran Zamani (4) , Karuppasamy Govindasamy (5) , Katsuhiko Suzuki (6) , Ismail Laher (7) , Hassane Zouhal (8)

1 Razi University of Kermanshah
2 ATU - Allameh Tabataba’i University
3 UC - University of Coimbra [Portugal]
4 Payame Noor University
5 SRM - SRM Institute of Science and Technology
6 Faculty of Science and Engineering [Waseda]
7 UBC - University of British Columbia
8 M2S - Laboratoire Mouvement Sport Santé

Thermoregulation is a homeostatic mechanism that is disrupted in some neurological diseases. Patients with multiple sclerosis (MS) are susceptible to increases in body temperature, especially with more severe neurological signs. This condition can become intolerable when these patients suffer febrile infections such as coronavirus disease-2019 (COVID-19). We review the mechanisms of hyperthermia in patients with MS, and they may encounter when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Finally, the thermoregulatory role and relevant adaptation to regular physical exercise are summarized.

Mots clés: ANS Autonomic nervous system; APN; Adiponectin; CNS; Central nervous system; COVID-19; Coronavirus disease-2019; EDHF; Endothelial-derived hyperpolarizing factor; MS; Multiple sclerosis; NLRP3; NLR family pyrin domain containing 3; NO; Nitric oxide; PACAP; Pituitary adenylate cyclase-activating polypeptide; PAMPs; Pathogen-associated molecular patterns; PGE(2); Prostaglandin E(2); PGs; Prostaglandins; ROS; Reactive oxygen species; SARS-CoV-2; severe acute respiratory syndrome coronavirus 2; SNS; Sympathetic nervous system; TRPV-1; Transient receptor potential vanilloid type 1; VDP; Vascular-dilating prostanoids; VEGF; Vascular endothelial growth factor; VIP; Vasoactive intestinal peptide; eNOS; Endothelial nitric oxide synthase; exercise; sweat gland; thermoregulation

Domaines: Sciences du Vivant [q-bio]; Physiologie [q-bio.TO]

Omid Razi, Bakhtyar Tartibian, Ana Maria Teixeira, Nastaran Zamani, Karuppasamy Govindasamy, et al.. Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise. Multiple Sclerosis and Related Disorders, 2022, 59, pp.103557. ⟨10.1016/j.msard.2022.103557⟩. ⟨hal-03555264⟩