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Chemistry, Oncogenesis, Stress and SignalingU Inserm 1242 |  |
Journal articles
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo
Pierre Jean Le Reste
1, 2, 3
R Pineau
1, 2, 3
Konstantinos Voutetakis
4
J Samal
5
Gwenaele Jegou
1, 2, 3
Stéphanie Lhomond
5
Adrienne M Gorman
5
Afshin Samali
5
John B Patterson
6
Q Zeng
6
Abhay Pandit
5
Marc Aubry
7
Nicolas Soriano
7
Amandine Etcheverry
8
Aristotelis Chatziioannou
9
Jean Mosser
7, 10
Tony Avril
1, 2, 3
Eric Chevet
1, 2, 3, *
*
Corresponding author
Pierre Jean Le Reste 1, 2, 3
Author
R Pineau 1, 2, 3
Author
Konstantinos Voutetakis 4
Author
J Samal 5
Author
Gwenaele Jegou 1, 2, 3
Author
Stéphanie Lhomond 5
Author
Adrienne M Gorman 5
Author
Afshin Samali 5
Author
John B Patterson 6
Author
Q Zeng 6
Author
Abhay Pandit 5
Author
Marc Aubry 7
Author IdHAL : marc-aubry ORCID : https://orcid.org/0000-0002-6954-8141
Nicolas Soriano 7
Author
Amandine Etcheverry 8
Author IdHAL : amandine-etcheverry ORCID : https://orcid.org/0000-0003-4092-8308
Aristotelis Chatziioannou 9
Author
Jean Mosser 7, 10
Author
Tony Avril 1, 2, 3
Author
Eric Chevet 1, 2, 3
Correspondent author
1
COSS - Chemistry, Oncogenesis, Stress and Signaling (Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CRLCC - CRLCC Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1242 (101, rue de Tolbiac, 75013 Paris - France)
2
CRLCC - CRLCC Eugène Marquis (Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX - France)
3
REACT - Rennes Brain Cancer Team (Rennes Brain Cancer Team (REACT), Rennes, France - France)
4
UTH - University of Thessaly [Volos] (Argonafton & Filellinon, 38221 Volos - Greece)
6
Fosun Orinove PharmaTech Inc.[Newbury Park, CA] (United States)
7
IGDR - Institut de Génétique et Développement de Rennes (Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6290 (France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
8
CHU Pontchaillou [Rennes] (2 Rue Henri le Guilloux, 35000 Rennes - France)
10
SFR UMS CNRS 3480 - INSERM 018 - Biosit : biologie, santé, innovation technologique (Campus de Villejean - Santé - Bâtiment 8
2 rue du Professeur Léon Bernard
35043 Rennes - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : US_S 018 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMS 3480 (France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
Abstract : Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed an immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-02959985
Contributor : Laurent Jonchère <>
Submitted on : Thursday, November 19, 2020 - 11:59:45 AM
Last modification on : Thursday, January 14, 2021 - 11:28:19 AM
Contributor : Laurent Jonchère <>
Submitted on : Thursday, November 19, 2020 - 11:59:45 AM
Last modification on : Thursday, January 14, 2021 - 11:28:19 AM
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Identifiers
- HAL Id : hal-02959985, version 1
- DOI : 10.1016/j.canlet.2020.08.028
- PUBMED : 32882336
Collections
UNIV-RENNES1 | UNIV-RENNES | UR1-UFR-SVE | OSS | BIOSIT | IGDR | MARQUIS | FNCLCC | CNRS
Citation
Pierre Jean Le Reste, R Pineau, Konstantinos Voutetakis, J Samal, Gwenaele Jegou, et al.. Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. Cancer Letters, Elsevier, 2020, 494, pp.73-83. ⟨10.1016/j.canlet.2020.08.028⟩. ⟨hal-02959985⟩
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