Skip to Main content Skip to Navigation
Journal articles

Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

Abstract : Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed an immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy.
Document type :
Journal articles
Complete list of metadatas

Cited literature [29 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02959985
Contributor : Laurent Jonchère <>
Submitted on : Thursday, November 19, 2020 - 11:59:45 AM
Last modification on : Thursday, January 14, 2021 - 11:28:19 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-03-01

Please log in to resquest access to the document

Identifiers

Citation

Pierre Jean Le Reste, R Pineau, Konstantinos Voutetakis, J Samal, Gwenaele Jegou, et al.. Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. Cancer Letters, Elsevier, 2020, 494, pp.73-83. ⟨10.1016/j.canlet.2020.08.028⟩. ⟨hal-02959985⟩

Share

Metrics

Record views

29