Significant decrease in interval colorectal cancer incidence after implementing immunochemical testing in a multiple-round guaiac-based screening programme - Chemistry Oncogenesis Stress Signaling Accéder directement au contenu
Article Dans Une Revue British Journal of Cancer Année : 2021

Significant decrease in interval colorectal cancer incidence after implementing immunochemical testing in a multiple-round guaiac-based screening programme

Résumé

Background and aims: We aimed to evaluate the effects of switching to faecal immunochemical testing (FIT) on the cumulative 2-year incidence rate of interval cancers, interval cancer rate and test sensitivity within a mature population-based colorectal cancer screening programme consisting of six rounds of biennial guaiac faecal occult blood testing (gFOBT).Methods: The FIT results were compared with those of gFOBT used in each of the previous two rounds. For the three rounds analysed, 279,041 tests were performed by 156,186 individuals. Logistic regression analysis was used to determine interval cancer risk factors (Poisson regression) and to compare the sensitivity of FIT to gFOBT.Results: There were 612 cases of screen-detected cancers and 209 cases of interval cancers. The sex- and age-adjusted cumulative 2-year incidence rates of interval cancers were 55.7 (95% CI, 45.3-68.5), 42.4 (95% CI, 32.6-55.2) and 15.8 (95% CI, 10.9-22.8) per 100,000 person-years after the last two rounds of gFOBT and FIT, respectively. The FIT/gFOBT incidence rate ratio was 0.38 [95% CI, 0.27-0.54] (P < 0.001). Sex- and age-adjusted sensitivity was significantly higher with FIT than with gFOBT (OR = 6.70 [95% CI, 4.48-10.01], P < 0.0001).Conclusions: This population-based study revealed a dramatic decrease in the cumulative incidence rates of interval cancers after switching from gFOBT to FIT. These data provide an additional incentive for countries still using gFOBT to switch to FIT.

Domaines

Cancer
Fichier principal
Vignette du fichier
Bretagne et al - 2021 - Significant decrease in interval colorectal cancer incidence.pdf (900.53 Ko) Télécharger le fichier
Bretagne_41416_2021_1546_MOESM1_ESM.pdf (1.91 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03367998 , version 1 (27-10-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Jean-François Bretagne, Aurore Carlo, Christine Piette, Chloé Rousseau, Mathilde Cosson, et al.. Significant decrease in interval colorectal cancer incidence after implementing immunochemical testing in a multiple-round guaiac-based screening programme. British Journal of Cancer, 2021, 125 (11), pp.1494-1502. ⟨10.1038/s41416-021-01546-z⟩. ⟨hal-03367998⟩
94 Consultations
35 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More