Involvement of Kynurenine Pathway in Hepatocellular Carcinoma - Chemistry Oncogenesis Stress Signaling Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2021

Involvement of Kynurenine Pathway in Hepatocellular Carcinoma

Résumé

As the second and third leading cancer-related death in men and the world, respectively, primary liver cancer remains a major concern to human health. Despite advances in diagnostic technology, patients with primary liver cancer are often diagnosed at an advanced stage. Treatment options for patients with advanced hepatocarcinoma (HCC) are limited to systemic treatment with multikinase inhibitors and immunotherapy. Furthermore, the 5-year survival rate for these late-stage HCC patients is approximately 12% worldwide. There is an unmet need to identify novel treatment options and/or sensitive blood-based biomarker(s) to detect this cancer at an early stage. Given that the liver harbours the largest proportion of immune cells in the human body, understanding the tumour-immune microenvironment has gained increasing attention as a potential target to treat cancer. The kynurenine pathway (KP) has been proposed to be one of the key mechanisms used by the tumour cells to escape immune surveillance for proliferation and metastasis. In an inflammatory environment such as cancer, the KP is elevated, suppressing local immune cell populations and enhancing tumour growth. In this review, we collectively describe the roles of the KP in cancer and provide information on the latest research into the KP in primary liver cancer.
Fichier principal
Vignette du fichier
cancers-13-05180.pdf (1.8 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03420190 , version 1 (09-11-2021)

Licence

Paternité

Identifiants

Citer

Shivani Krishnamurthy, David Gilot, Seong Beom Ahn, Vincent Lam, Joo-Shik Shin, et al.. Involvement of Kynurenine Pathway in Hepatocellular Carcinoma. Cancers, 2021, 13 (20), ⟨10.3390/cancers13205180⟩. ⟨hal-03420190⟩
32 Consultations
61 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More