A chemomechanobiological model of the long-term healing response of arterial tissue to a clamping injury - CIS / STBio : Surfaces et Tissus Biologiques Accéder directement au contenu
Article Dans Une Revue Frontiers in Bioengineering and Biotechnology Année : 2021

A chemomechanobiological model of the long-term healing response of arterial tissue to a clamping injury

Résumé

Vascular clamping often causes injury to arterial tissue, leading to a cascade of cellular and extracellular events. A reliable in silico prediction of these processes following vascular injury could help us to increase our understanding thereof, and eventually optimize surgical techniques or drug delivery to minimize the amount of long-term damage. However, the complexity and interdependency of these events make translation into constitutive laws and their numerical implementation particularly challenging. We introduce a finite element simulation of arterial clamping taking into account acute endothelial denudation, damage to extracellular matrix, and smooth muscle cell loss. The model captures how this causes tissue inflammation and deviation from mechanical homeostasis, both triggering vascular remodeling. A number of cellular processes are modeled, aiming at restoring this homeostasis, i.e., smooth muscle cell phenotype switching, proliferation, migration, and the production of extracellular matrix. We calibrated these damage and remodeling laws by comparing our numerical results to in vivo experimental data of clamping and healing experiments. In these same experiments, the functional integrity of the tissue was assessed through myograph tests, which were also reproduced in the present study through a novel model for vasodilator and -constrictor dependent smooth muscle contraction. The simulation results show a good agreement with the in vivo experiments. The computational model was then also used to simulate healing beyond the duration of the experiments in order to exploit the benefits of computational model predictions. These results showed a significant sensitivity to model parameters related to smooth muscle cell phenotypes, highlighting the pressing need to further elucidate the biological processes of smooth muscle cell phenotypic switching in the future
Fichier principal
Vignette du fichier
ART148.pdf (1.08 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03139778 , version 1 (12-02-2021)

Identifiants

Citer

Lauranne Maes, Julie Vastmans, Stéphane Avril, Nele Famaey. A chemomechanobiological model of the long-term healing response of arterial tissue to a clamping injury. Frontiers in Bioengineering and Biotechnology, 2021, 8, pp.589889. ⟨10.3389/fbioe.2020.589889⟩. ⟨hal-03139778⟩
52 Consultations
39 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More