Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?

Jean-Philippe Bastard (1, 2, 3) , Soraya Fellahi (1, 2, 3) , Axel Regeniter (4) , Jacqueline Capeau (1, 5) , Pierre Ronco (6, 2) , Emmanuelle Plaisier (2, 6)

1 Pathologies biliaires, fibrose et cancer du foie [CRSA]
2 CHU Tenon [AP-HP]
3 CHU Saint-Antoine [AP-HP]
4 Medica medical Laboratories
5 CRSA - Centre de Recherche Saint-Antoine
6 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation

The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. This short overview proposes to illustrate the diagnostic and prognostic usefulness of UPP in different common clinical situations.

Mots clés: Glomerular disease; Proteinuria; Tubulopathy

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]

Jean-Philippe Bastard, Soraya Fellahi, Axel Regeniter, Jacqueline Capeau, Pierre Ronco, et al.. Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?. Clinical Biochemistry, 2019, 65, pp.1-6. ⟨10.1016/j.clinbiochem.2019.01.006⟩. ⟨hal-02380905⟩