High level of soluble HLA-G in amniotic fluid is correlated with congenital transmission of Toxoplasma gondii. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Clinical Immunology Année : 2011

High level of soluble HLA-G in amniotic fluid is correlated with congenital transmission of Toxoplasma gondii.

Résumé

The expression of human leukocyte antigen (HLA)-G on cytotrophoblast cells contributes to maternal-fetal tolerance. Soluble forms of HLA-G (sHLA-G) can be detected in amniotic fluid (AF) and a decrease of sHLA-G is known to be correlated to fetal loss. In this work we investigated the role of sHLA-G in the transplacental passage of the protozoan parasite Toxoplasma gondii, responsible for congenital toxoplasmosis in about 30% of fetuses when primary infection (PI) occurs during pregnancy. We determined the sHLA-G concentration in 61 AF from women with PI and 24 controls. Our results showed higher sHLA-G levels in AF from PI than in controls (p<0.001). Moreover sHLA-G level from congenitally infected fetuses (n=12) was higher than in fetus in whom congenital infection was ruled out (n=49, p<0.05). These data suggest that sHLA-G could participate in immunomodulation necessary to avoid fetal loss due to Toxoplasma infection, but that over-expression could favor congenital transmission.

Dates et versions

hal-00682013 , version 1 (23-03-2012)

Identifiants

Citer

Florence Robert-Gangneux, Jean-Pierre Gangneux, Nicolas Vu, Sylvie Jaillard, Claude Guiguen, et al.. High level of soluble HLA-G in amniotic fluid is correlated with congenital transmission of Toxoplasma gondii.. Clinical Immunology, 2011, 138 (2), pp.129-34. ⟨10.1016/j.clim.2010.12.004⟩. ⟨hal-00682013⟩
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