Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds--a critical review. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2012

Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds--a critical review.

Résumé

Quaternary ammonium compounds (QACs) are widely distributed in hospitals, industry and cosmetics. Little attention has been focused on the potential impact of QACs on the emergence of antibiotic resistance in patients and the environment. To assess this issue, we conducted a literature review on QAC chemical structure, fields of application, mechanism of action, susceptibility testing, prevalence, and co- or cross-resistance to antibiotics. Special attention was paid to the effects of QACs on microflora; in particular, the issue of the potential of QACs for applying selective pressure on multiple-antibiotic-resistant organisms was raised. It was found that there is a lack of standardised procedures for interpreting susceptibility test results. QACs have different impacts on the minimum inhibitory concentrations of antibacterials depending on the antibacterial compound investigated, the resistance genes involved, the measuring methodology and the interpretative criteria. The unmet needs for adequate detection of reduced susceptibility to QACs and antibiotics include (i) a consensus definition for resistance, (ii) epidemiological cut-off values and (iii) clinical resistance breakpoints. This review advocates the design of international guidelines for QAC use.

Dates et versions

hal-00796476 , version 1 (04-03-2013)

Identifiants

Citer

Sylvie Buffet-Bataillon, Pierre Tattevin, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon. Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds--a critical review.. International Journal of Antimicrobial Agents, 2012, 39 (5), pp.381-9. ⟨10.1016/j.ijantimicag.2012.01.011⟩. ⟨hal-00796476⟩
154 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More