Lobarin from the Sumatran lichen, Stereocaulon halei.

Friardi Ismed (1) , Françoise Lohézic-Le Dévéhat (1) , Olivier Delalande (2) , Sourisak Sinbandhit , Amri Bakhtiar , Joël Boustie (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 Structures et interactions moléculaires

The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed.

Mots clés: Lichen; Stereocaulon halei; Photoprotection; Diphenyl ether; Pseudodepsidone; Antioxidant; XANTHOPARMELIA-SCABROSA; ANTIOXIDANT ACTIVITY; ACID; CONSTITUENTS; METABOLITES; DEPSIDONE

Domaines: Chimie thérapeutique

Friardi Ismed, Françoise Lohézic-Le Dévéhat, Olivier Delalande, Sourisak Sinbandhit, Amri Bakhtiar, et al.. Lobarin from the Sumatran lichen, Stereocaulon halei.. Fitoterapia, 2012, 83 (8), pp.1693-8. ⟨10.1016/j.fitote.2012.09.025⟩. ⟨hal-00813194⟩