Sonde endoluminale combinant l'IRM à haute résolution spatiale et la spectroscopie optique en vue du diagnostic précoce du cancer colorectal: développement instrumental, étude sur fantômes et premiers tests in vivo chez le lapin
Résumé
Conventional white light endoscopy (WLE) coupled to histology is considered as the gold standard today for colorectal cancer diagnosis. However during the early staged, colorectal cancer is very often characterized by flat adenomas which develop just underneath the mucosal surface. The use of WLE which is heavely based on the detection of morphological changes becomes quite delicate due to subtle or quasi-invisible morphological changes of the colonic lining. several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actuel techniques in doing so. We hereby present a novel technique where High spatial Resolution MRI (HR-MRI) is combined with autofluorescence and reflectance spectroscopy in a bimodal endoluminal probe to extract morphological data and biochemical information respectively. the design and conception of the endoluminal probe along with the preliminary results obtained in-vitro, and in-vivo on a rabbit are presented and discussed