K. Abdellaoui, M. Boustta, M. Vert, H. Morjani, and M. Manfait, Metabolite-derived artificial 444 polymers designed for drug targeting, cell penetration and bioresorption., Eur, J. Pharm. Sci, vol.6, pp.61-73, 1998.

L. Barraud, P. Merle, E. Soma, L. Lefrançois, S. Guerret et al., Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo, Journal of Hepatology, vol.42, issue.5, pp.736-743, 2005.
DOI : 10.1016/j.jhep.2004.12.035

. Traité-de-chimie-thérapeutique, « Médicaments anti-tumoraux et perspectives dans les 458 traitements des cancers ». Edition TEC et DOC, pp.3-23

S. Cammas, I. Renard, K. Boutault, and P. Guérin, A novel synthesis of optically active 4-benzyloxy- and 4-alkyloxycarbonyl-2-oxetanones, Tetrahedron: Asymmetry, vol.4, issue.8, pp.1925-1930, 1993.
DOI : 10.1016/S0957-4166(00)80433-4

S. Cammas, Y. Nagasaki, and K. Kataoka, Heterobifunctional Poly(ethylene oxide): Synthesis of .alpha.-Methoxy-.omega.-amino and .alpha.-Hydroxy-.omega.-amino PEOs with the Same Molecular Weights, Bioconjugate Chemistry, vol.6, issue.2, p.465, 1995.
DOI : 10.1021/bc00032a011

S. Cammas, I. Renard, V. Langlois, and P. Guérin, Poly(??-malic acid): obtaining high molecular weights by improvement of the synthesis route, Polymer, vol.37, issue.18, pp.4215-4220, 1996.
DOI : 10.1016/0032-3861(96)00204-2

S. Cammas, M. M. Béar, A. Harada, P. Guérin, and K. Kataoka, New macromolecular micelles based on degradable amphiphilic block copolymers of malic acid and malic acid ester, Macromolecular Chemistry and Physics, vol.201, issue.3, pp.355-364, 2000.
DOI : 10.1002/(SICI)1521-3935(20000201)201:3<355::AID-MACP355>3.0.CO;2-9

M. Fujita, N. Karabalin, T. Sasaki, K. B. Black, E. Holler et al., Inhibition of brain 479 tumor growth by intravenous poly(?-L-malic acid) nanobioconjugate with pH-dependent drug release, p.480, 2010.

A. Elsaesser and C. V. Howard, Toxicology of nanoparticles, Advanced Drug Delivery Reviews, vol.64, issue.2, pp.129-137, 2012.
DOI : 10.1016/j.addr.2011.09.001

J. Y. Ljubimova, Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier 487 reduces glioma angiogenesis, Angiogenesis, vol.9, pp.183-191, 2006.

E. Holler, K. L. Black, and J. Y. Ljubimova, Brain tumor tandem targeting using a combination of 491, 2007.

J. Fogh and G. Trempe, Human Tumor Cells in Vitro, Ed. J. Fogh, pp.115-494, 1975.
DOI : 10.1007/978-1-4757-1647-4

P. Gripon, S. Rumin, S. Urban, L. Seyec, J. Glaise et al., Infection of a human hepatoma cell line by hepatitis B virus, Proc. 501, 2002.

K. Hasegawa and N. Kokudo, Surgical treatment of hepatocellular carcinoma, Surgery Today, vol.134, issue.9350, pp.833-843, 2009.
DOI : 10.1007/s00595-008-4024-z

S. Cammas-marion, New functional degradable and bio-compatible nanoparticles based on 508, 2012.

T. Ishikawa, The ATP-dependent glutathione S-conjugate export pump, Trends in Biochemical Sciences, vol.17, issue.11, pp.17-463, 1992.
DOI : 10.1016/0968-0004(92)90489-V

R. K. Jain and T. Stylianopoulos, Delivering nanomedicine to solid tumors, Nature Reviews Clinical Oncology, vol.3, issue.11, pp.7-653, 2010.
DOI : 10.1038/nrclinonc.2010.139

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065247

Q. Ren and X. Fang, Self-aggregated pegylated poly(trimethylene carbonate) nanoparticles 517 decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors, p.518, 2011.

S. Y. Kim, S. H. Cho, Y. M. Lee, and L. Y. Chu, Biotin-conjugated block copolymeric nanoparticles as tumor-targeted drug delivery systems, Macromolecular Research, vol.12, issue.7, pp.646-655, 2007.
DOI : 10.1007/BF03218945

P. Loyer, Highly efficient gene transfer into hepatocyte-like cells: new means for drug 532 metabolism and toxicity studies, Biotechnol. J, vol.5, pp.314-320, 2010.

O. Flores, M. Masserini, K. Andrieux, and P. Couvreur, Versatile and efficient targeting using a 541, p.22, 2012.

J. Y. Ljubimova, M. Fujita, N. M. Khazenzon, B. S. Lee, S. Wachsmann-hogiu et al., Nanoconjugate based on polymalic acid for tumor targeting, Chemico-Biological Interactions, vol.171, issue.2, p.546, 2008.
DOI : 10.1016/j.cbi.2007.01.015

M. Barbosa, M. E. Cammas, S. Appel, M. Ponchel, and G. , Investigation of the degradation 549 mechanisms of poly(malic acid) esters in vitro and their, p.550, 2004.

R. Misra, S. Acharya, and S. K. Sahoo, Cancer nanotechnology: application of nanotechnology in cancer therapy, Drug Discovery Today, vol.15, issue.19-20, pp.842-850, 2010.
DOI : 10.1016/j.drudis.2010.08.006

S. Osanai and K. Nakamura, Effects of complexation between liposome and poly(malic acid) on aggregation and leakage behaviour, Biomaterials, vol.21, issue.9, pp.867-876, 2000.
DOI : 10.1016/S0142-9612(99)00210-0

Y. B. Patil, U. S. Toti, A. Khdair, L. Ma, and J. Panyam, Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery, Biomaterials, vol.30, issue.5, pp.859-866, 2009.
DOI : 10.1016/j.biomaterials.2008.09.056

R. Rahbari, T. Sheahan, V. Modes, P. Collier, C. Macfarlane et al., A novel L1 571 retrotransposon marker for HeLa cell line identification, BioTechniques, vol.46, issue.4, pp.277-284, 2009.

L. H. Reddy and P. Couvreur, Nanotechnology for therapy and imaging of liver diseases, Journal of Hepatology, vol.55, issue.6, p.574, 2011.
DOI : 10.1016/j.jhep.2011.05.039

B. Romberg, W. E. Hennink, and G. Strom, Sheddable Coatings for Long-Circulating Nanoparticles, Pharmaceutical Research, vol.16, issue.1, p.577, 2008.
DOI : 10.1007/s11095-007-9348-7

O. Thioune, H. Fessi, J. P. Devissaguet, and F. Puisieux, Preparation of pseudolatex by 580 nanoprecipitation: influence of the solvent nature on intrinsic viscosity and interaction constant, Int. J, p.581, 1997.

M. Vert and R. W. Lenz, Preparation and properties of poly?-malic acid: a functional polyester of 584 potential biomedical importance, Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.), vol.20, issue.1, pp.608-585, 1979.

J. Wu, M. H. Nantz, and M. A. Zern, Targeting Hepatocytes for Drug and Gene Delivery: Emerging 591, 2002.