Synthesis of stachybotrin C and all of its stereoisomers: structure revision.

Maiwenn Jacolot (1) , Mickael Jean (1) , Naresh Tumma , Arnaud Bondon (2, 3) , Srivari Chandrasekhar , Pierre van de Weghe (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 PRISM - Plate-forme Rennaise d'Imagerie et Spectroscopie Structurale et Métabolique
3 IGDR - Institut de Génétique et Développement de Rennes

We disclose the first total synthesis of stachybotrin C, a potent neuroprotective natural compound. All of the four stereoisomers have been prepared and fully characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters of the stachybotrin C.

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology

Maiwenn Jacolot, Mickael Jean, Naresh Tumma, Arnaud Bondon, Srivari Chandrasekhar, et al.. Synthesis of stachybotrin C and all of its stereoisomers: structure revision.. Journal of Organic Chemistry, 2013, 78 (14), pp.7169-75. ⟨10.1021/jo401116r⟩. ⟨hal-00862776⟩