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Journal articles
Unprecedented 17-residue peptaibiotics produced by marine-derived Trichoderma atroviride.
Abstract : In the course of investigations on marine-derived toxigenic fungi, five strains of Trichoderma atroviride were studied for their production of peptaibiotics. While these five strains were found to produce classical 19-residue peptaibols, three of them exhibited unusual peptidic sodium-adduct [M + 2 Na](2+) ion peaks at m/z between 824 and 854. The sequencing of these peptides led to two series of unprecedented 17-residue peptaibiotics based on the model Ac-XXX-Ala-Ala-XXX-XXX-Gln-Aib-Aib-Aib-Ala/Ser-Lxx-Aib-Pro-XXX-Aib-Lxx-[C(129) ]. The C-terminus of these new peptides was common to all of them, and its elemental formula C5 H9 N2 O2 was established by HR-MS. It could correspond to the cyclized form of N(δ) -hydroxyornithine which has already been observed at the C-terminus of various peptidic siderophores. The comparison of the sequences of 17- and 19-residue peptides showed similarities for positions 1-16. This observation seems to indicate a common biosynthesis pathway. Both new 17-residue peptaibiotics and 19-residue peptaibols exhibited weak in vitro cytotoxicities against KB cells.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00862780
Contributor : Arnaud Bondon <>
Submitted on : Tuesday, September 17, 2013 - 2:47:15 PM
Last modification on : Thursday, January 14, 2021 - 11:24:29 AM
Contributor : Arnaud Bondon <>
Submitted on : Tuesday, September 17, 2013 - 2:47:15 PM
Last modification on : Thursday, January 14, 2021 - 11:24:29 AM
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