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Elucidation by NMR solution of neurotensin in small unilamellar vesicle environment: molecular surveys for neurotensin receptor recognition.

Abstract : Neurotensin (NT) is a tridecapeptide, hormone in the periphery and neurotransmitter in the brain. We used high-resolution nuclear magnetic resonance (NMR) to resolve the three-dimensional structure of NT in a small unilamellar vesicle (SUV) environment. We demonstrate that if the dynamic of the association-dissociation processes of peptide to SUV binding is rapid enough, structural determination can be obtained by solution NMR experiments. Thus, according to the global dynamic of the system, SUVs seem to be an effective model to mimic biological membranes, especially since the lipid composition can be modified or sterols may be added to closely mimic the biological membranes studied. An animated Interactive 3D Complement (I3DC) is available in Proteopedia at http://proteopedia.org/w/Journal:JBSD:2.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00862783
Contributor : Arnaud Bondon <>
Submitted on : Tuesday, September 17, 2013 - 2:48:37 PM
Last modification on : Tuesday, May 26, 2020 - 11:30:04 PM

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Grégory da Costa, Arnaud Bondon, Olivier Delalande, Liza Mouret, Jean-Pierre Monti. Elucidation by NMR solution of neurotensin in small unilamellar vesicle environment: molecular surveys for neurotensin receptor recognition.. Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2013, 31 (8), pp.809-17. ⟨10.1080/07391102.2012.712459⟩. ⟨hal-00862783⟩

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