Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.

Ronan Garlantézec (1) , Charline Warembourg (1) , Christine Monfort (1) , Laurence Labat (2) , Juha Pulkkinen (3) , Luc Multigner (1) , Nathalie Bonvallot (1) , Cécile Chevrier (1) , Sylvaine Cordier (1)

1 Irset - Institut de recherche en santé, environnement et travail
2 Laboratoire de Toxicologie et Génopathies
3 Laboratory of Chemistry

BACKGROUND: Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. OBJECTIVE: To study the relation between women's exposure to glycol ethers and time to pregnancy. METHODS: Urine from randomly selected women in the PELAGIE mother-child cohort who had samples collected before 19 weeks of gestation was tested to measure eight glycol ether metabolites by chromatography coupled to mass spectrometry. Time to pregnancy was collected at the beginning of the pregnancy by asking women how many months they took to conceive. Associations between metabolite levels and time to pregnancy were estimated in 519 women with complete data using discrete-time Cox proportional hazards models to adjust for potential confounders. RESULTS: Glycol ether metabolites were detected in 6% (for ethoxyacetic acid) to 93% (for phenoxyacetic and butoxyacetic acids) of urine samples. Phenoxyacetic acid was the only metabolite with a statistically significant association with longer time to pregnancy (fecundability OR 0.82; 95% CI: 0.63, 1.06 for the second and third quartile combined; fecundability OR 0.70; 95% CI: 0.52, 0.95 for a fourth-quartile (≥1.38 mg/L) vs. first-quartile concentration (<0.14 mg/L)). This association remained stable after multiple sensitivity analyses. CONCLUSION: Phenoxyacetic acid, which was present in most of the urine samples tested in our study, was associated with increased time to pregnancy. This metabolite and its main parent compound, 2-phenoxyethanol, are plausible causes of decreased fecundability, but may also be surrogates for potential co-exposures frequently present in cosmetics.

Keywords: Pregnancy; PELAGIE Cohort; Urinary Glycol Ether Metabolites

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Santé publique et épidémiologie

Ronan Garlantézec, Charline Warembourg, Christine Monfort, Laurence Labat, Juha Pulkkinen, et al.. Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort.. Environmental Health Perspectives, 2013, 121 (10), pp.1167-73. ⟨10.1289/ehp.1206103⟩. ⟨hal-00866023⟩