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Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Saida Benzerka 1 Abdelmalek Bouraiou 1 Sofiane Bouacida 1 Thierry Roisnel 2 Chafia Bentchouala Farida Smati Bertrand Carboni 2 Ali Belfaitah 1
1 PHYSYNOR - Laboratoire des produits naturels d'origine végétal et de synthèse organique
2 ISCR - Institut des Sciences Chimiques de Rennes
Abstract : Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.
Keywords : 2-Phenylquinoline heterocycles crystal structure antimicrobial activity minimum inhibitory concentration
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00871959
Contributor : Alice Brébion <>
Submitted on : Friday, October 11, 2013 - 9:46:15 AM
Last modification on : Friday, July 10, 2020 - 4:14:59 PM

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UNIV-RENNES1 | CNRS | SCR-CD | ISCR | ISCR-PRATS | INC-CNRS | ISCR-CORINT | UR1-UFR-SPM | UNIV-RENNES | INSA-GROUPE | INSA-RENNES

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Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Thierry Roisnel, Chafia Bentchouala, et al.. Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents. Letters in Organic Chemistry, Bentham Science Publishers, 2013, 10 (2), pp.94-99. ⟨10.2174/1570178611310020005⟩. ⟨hal-00871959⟩

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