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Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Abstract : Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00871959
Contributor : Alice Brébion <>
Submitted on : Friday, October 11, 2013 - 9:46:15 AM
Last modification on : Friday, July 10, 2020 - 4:14:59 PM

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Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Thierry Roisnel, Chafia Bentchouala, et al.. Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents. Letters in Organic Chemistry, Bentham Science Publishers, 2013, 10 (2), pp.94-99. ⟨10.2174/1570178611310020005⟩. ⟨hal-00871959⟩

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