Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents

Saida Benzerka (1) , Abdelmalek Bouraiou (1) , Sofiane Bouacida (1) , Thierry Roisnel (2) , Chafia Bentchouala , Farida Smati , Bertrand Carboni (2) , Ali Belfaitah (1)

1 PHYSYNOR - Laboratoire des produits naturels d'origine végétal et de synthèse organique
2 ISCR - Institut des Sciences Chimiques de Rennes

Some new unfused tricyclic aromatic systems containing various heterocyclic cores were synthesized. These compounds were prepared in good yields via appropriate routes using 6-methyl-2-phenylquinoline-3-carbaldehyde as a key intermediate. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella thipymurium using the disk-diffusion method. The minimum inhibitory concentration (MIC) was determined for the tested compounds.

Keywords: 2-Phenylquinoline; heterocycles; crystal structure; antimicrobial activity; minimum inhibitory concentration

Domains: Chemical Sciences; Organic chemistry

Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Thierry Roisnel, Chafia Bentchouala, et al.. Synthesis of New 3-heteroaryl-2-phenylquinolines and their Pharmacological Activity as Antimicrobial Agents. Letters in Organic Chemistry, 2013, 10 (2), pp.94-99. ⟨10.2174/1570178611310020005⟩. ⟨hal-00871959⟩