Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones - Archive ouverte HAL Access content directly
Journal Articles Letters in Organic Chemistry Year : 2013

Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

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Abstract

An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
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hal-00871972 , version 1 (11-10-2013)

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Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berrée, Bertrand Carboni, et al.. Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones. Letters in Organic Chemistry, 2013, 10 (7), pp.463-467. ⟨10.2174/15701786113109990014⟩. ⟨hal-00871972⟩
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