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Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Imene Sehout Raouf Boulcina 1 Boudjemaa Boumoud 1 Fabienne Berrée 2 Bertrand Carboni 2 Abdelmadjid Debache 1
1 PHYSYNOR - Laboratoire des produits naturels d'origine végétal et de synthèse organique
2 ISCR - Institut des Sciences Chimiques de Rennes
Abstract : An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
Keywords : Multicomponent reaction one-pot synthesis Biginelli reaction 4dihydropyrimidin-2(1H)-ones/thiones ascorbic acid
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00871972
Contributor : Alice Brébion <>
Submitted on : Friday, October 11, 2013 - 9:56:26 AM
Last modification on : Friday, July 10, 2020 - 4:15:01 PM

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UNIV-RENNES1 | CNRS | ISCR | INC-CNRS | ISCR-CORINT | UR1-UFR-SPM | UNIV-RENNES | INSA-GROUPE | INSA-RENNES

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Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berrée, Bertrand Carboni, et al.. Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones. Letters in Organic Chemistry, Bentham Science Publishers, 2013, 10 (7), pp.463-467. ⟨10.2174/15701786113109990014⟩. ⟨hal-00871972⟩

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