Oc031--Generic Substitution Of Antiepileptic Drug (Aed) And Loss Of Seizure Control: A Population-Based Case-Crossover Study

Elisabeth Polard (1) , André Happe (1) , Emmanuel Nowak (1) , Arnaud Biraben (2) , Emmanuel Oger (1)

1 CIC - Centre d'Investigation Clinique [Rennes]
2 Service de Neurologie [Rennes] = Neurology [Rennes]

There are still controversies over pill substitution among AEDs: some studies claimed that switching between brand and generic AED (generic substitution) can lead to breakthrough seizures; other studies have refuted these concerns. France and some US states recommend limiting substitution of generic AED. We aimed at further estimating the association between generic substitution and loss of seizure control.

Domains: Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology

Elisabeth Polard, André Happe, Emmanuel Nowak, Arnaud Biraben, Emmanuel Oger. Oc031--Generic Substitution Of Antiepileptic Drug (Aed) And Loss Of Seizure Control: A Population-Based Case-Crossover Study. 11th Conference of the European Association for Clinical Pharmacology and Therapeutics, Aug 2013, Genève, Switzerland. pp.e13, ⟨10.1016/j.clinthera.2013.07.030⟩. ⟨hal-00874515⟩