Transmitted drug resistance in French HIV-2-infected patients.

Charlotte Charpentier (1) , Benoit Visseaux (1) , Antoine Bénard (2) , Gilles Peytavin (3) , Florence Damond (1) , Céline Roy (2) , Audrey Taieb (2) , Geneviève Chêne (2) , Sophie Matheron (4) , Francoise Brun-Vézinet (1) , Diane Descamps (1) , Christian Michelet (5)

1 Laboratoire de Virologie
2 Epidémiologie et Biostatistique [Bordeaux]
3 Service de pharmacie
4 Service des maladies infectieuses et tropicales
5 Irset - Institut de recherche en santé, environnement et travail

We report the first transmitted drug resistance survey study in HIV-2-infected patients living in France. The prevalence of transmitted drug resistance was 5.0% (95% confidence interval, 0.1-9.9) with mutations detected only in protease, not in reverse transcriptase. In this series, 10% of patients displayed X4/dual-mixed viruses. These findings classified the rate of transmitted drug resistance in the HIV-2 French Cohort as low prevalence.

Domaines: Toxicologie

Charlotte Charpentier, Benoit Visseaux, Antoine Bénard, Gilles Peytavin, Florence Damond, et al.. Transmitted drug resistance in French HIV-2-infected patients.. AIDS. Official journal of the international AIDS Society, 2013, 27 (10), pp.1671-4. ⟨10.1097/QAD.0b013e32836207f3⟩. ⟨hal-00875077⟩