E. Samarut, R. , and C. , Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development, Molecular and Cellular Endocrinology, vol.348, issue.2, pp.348-360, 2012.
DOI : 10.1016/j.mce.2011.03.025

B. Ju, V. Lunyak, V. Perissi, I. Garcia-bassets, and D. Rose, A Topoisomerase II??-Mediated dsDNA Break Required for Regulated Transcription, Science, vol.312, issue.5781, pp.1798-1802, 2006.
DOI : 10.1126/science.1127196

R. Pavri, B. Lewis, T. Kim, F. Dilworth, and H. Erdjument-bromage, PARP-1 Determines Specificity in a Retinoid Signaling Pathway via Direct Modulation of Mediator, Molecular Cell, vol.18, issue.1, pp.83-96, 2005.
DOI : 10.1016/j.molcel.2005.02.034
URL : https://hal.archives-ouvertes.fr/hal-00129955

P. Martin, V. Lardeux, and P. Lefebvre, The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction, Nucleic Acids Research, vol.33, issue.13, pp.4311-4321, 2005.
DOI : 10.1093/nar/gki745

B. Lefebvre, C. Brand, S. Flajollet, and P. Lefebvre, Down-Regulation of the Tumor Suppressor Gene Retinoic Acid Receptor ??2 through the Phosphoinositide 3-Kinase/Akt Signaling Pathway, Molecular Endocrinology, vol.20, issue.9, pp.2109-2121, 2006.
DOI : 10.1210/me.2005-0321

B. Lefebvre, K. Ozato, and P. Lefebvre, Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation, EMBO Reports, vol.3, issue.4, p.340, 2002.
DOI : 10.1093/embo-reports/kvf066

A. Dey, F. Chitsaz, A. Abbasi, T. Misteli, and K. Ozato, The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis, Proceedings of the National Academy of Sciences, vol.100, issue.15, p.8758, 2003.
DOI : 10.1073/pnas.1433065100

Z. Yang, J. Yik, R. Chen, N. He, and M. Jang, Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4, Molecular Cell, vol.19, issue.4, pp.535-545, 2005.
DOI : 10.1016/j.molcel.2005.06.029

A. Zippo, R. Serafini, M. Rocchigiani, S. Pennacchini, and A. Krepelova, Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation, Cell, vol.138, issue.6, pp.1122-1136, 2009.
DOI : 10.1016/j.cell.2009.07.031

P. Lefebvre, A. Mouchon, B. Lefebvre, and P. Formstecher, Binding of Retinoic Acid Receptor Heterodimers to DNA: A ROLE FOR HISTONES NH2 TERMINI, Journal of Biological Chemistry, vol.273, issue.20, pp.12288-12295, 1998.
DOI : 10.1074/jbc.273.20.12288

S. Flajollet, B. Lefebvre, C. Rachez, and P. Lefebvre, Distinct Roles of the Steroid Receptor Coactivator 1 and of MED1 in Retinoid-induced Transcription and Cellular Differentiation, Journal of Biological Chemistry, vol.281, issue.29, pp.20338-20348, 2006.
DOI : 10.1074/jbc.M603023200
URL : https://hal.archives-ouvertes.fr/inserm-00079314

P. Amann, S. Eichmüller, J. Schmidt, and A. Bazhin, Regulation of Gene Expression by Retinoids, Current Medicinal Chemistry, vol.18, issue.9, pp.1405-1412, 2011.
DOI : 10.2174/092986711795029618

E. Smith, C. Lin, and A. Shilatifard, The super elongation complex (SEC) and MLL in development and disease, Genes & Development, vol.25, issue.7, pp.661-672, 2011.
DOI : 10.1101/gad.2015411

Z. Luo, C. Lin, E. Guest, A. Garrett, and N. Mohaghegh, The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output, Molecular and Cellular Biology, vol.32, issue.13, pp.2608-2617, 2012.
DOI : 10.1128/MCB.00182-12

C. Depoix, M. Delmotte, P. Formstecher, and P. Lefebvre, Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. a novel mechanism of action for retinoid antagonists, J Biol Chem, vol.276, pp.9452-9459, 2001.

D. Falco, G. Bagella, L. Claudio, P. De, L. Fu et al., Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation, Oncogene, vol.19, issue.3, pp.373-379, 2000.
DOI : 10.1038/sj.onc.1203305

C. Rachez, Z. Suldan, J. Ward, C. Chang, and D. Burakov, A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free??system, Genes & Development, vol.12, issue.12, pp.1787-1800, 1998.
DOI : 10.1101/gad.12.12.1787

P. Sacchetti, R. Carpentier, P. Segard, C. Olive-cren, and P. Lefebvre, Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1, Nucleic Acids Research, vol.34, issue.19, pp.5515-5527, 2006.
DOI : 10.1093/nar/gkl712

C. Brand, P. Segard, P. Plouvier, P. Formstecher, and P. Danze, Selective alteration of gene expression in response to natural and synthetic retinoids, BMC Pharmacology, vol.2, issue.1, p.13, 2002.
DOI : 10.1186/1471-2210-2-13
URL : https://hal.archives-ouvertes.fr/inserm-00124452

B. Lefebvre, Y. Benomar, A. Guedin, A. Langlois, and N. Hennuyer, Proteasomal degradation of retinoid X receptor ?? reprograms transcriptional activity of PPAR?? in obese mice and humans, Journal of Clinical Investigation, vol.120, issue.5, pp.1454-1468, 2010.
DOI : 10.1172/JCI38606DS1

O. Briand, A. Helleboid-chapman, M. Ploton, N. Hennuyer, and R. Carpentier, The Nuclear Orphan Receptor Nur77 Is a Lipotoxicity Sensor Regulating Glucose-Induced Insulin Secretion in Pancreatic ??-Cells, Molecular Endocrinology, vol.26, issue.3, pp.399-413, 2012.
DOI : 10.1210/me.2011-1317

R. Metivier, G. Penot, M. Hubner, G. Reid, and H. Brand, Estrogen Receptor-?? Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter, Cell, vol.115, issue.6, pp.751-763, 2003.
DOI : 10.1016/S0092-8674(03)00934-6

A. Leray, F. Riquet, E. Richard, C. Spriet, and D. Trinel, Optimized protocol of a frequency domain fluorescence lifetime imaging microscope for FRET measurements, Microscopy Research and Technique, vol.103, issue.5, pp.371-379, 2009.
DOI : 10.1002/jemt.20665

S. Nagpal, S. Friant, H. Nakshatri, and P. Chambon, RARs and RXRs evidence for 2 autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo, EMBO J, vol.12, pp.2349-2360, 1993.

C. Rochette-egly, S. Adam, M. Rossignol, J. Egly, and P. Chambon, Stimulation of RAR?? Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7, Cell, vol.90, issue.1, pp.97-107, 1997.
DOI : 10.1016/S0092-8674(00)80317-7

A. Keriel, A. Stary, A. Sarasin, C. Rochetteegly, and J. Egly, XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RAR??, Cell, vol.109, issue.1, pp.125-135, 2002.
DOI : 10.1016/S0092-8674(02)00692-X

M. Jang, K. Mochizuki, M. Zhou, H. Jeong, and J. Brady, The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription, Molecular Cell, vol.19, issue.4, pp.523-534, 2005.
DOI : 10.1016/j.molcel.2005.06.027

M. Ottinger, T. Christalla, K. Nathan, M. Brinkmann, and A. Viejo-borbolla, Kaposi's Sarcoma-Associated Herpesvirus LANA-1 Interacts with the Short Variant of BRD4 and Releases Cells from a BRD4- and BRD2/RING3-Induced G1 Cell Cycle Arrest, Journal of Virology, vol.80, issue.21, pp.10772-10786, 2006.
DOI : 10.1128/JVI.00804-06

S. Beausoleil, M. Jedrychowski, D. Schwartz, J. Elias, and J. Villen, Large-scale characterization of HeLa cell nuclear phosphoproteins, Proceedings of the National Academy of Sciences, vol.101, issue.33, pp.12130-12135, 2004.
DOI : 10.1073/pnas.0404720101

F. Yang, X. Lio, M. Sharma, M. Zarnegar, and B. Lim, Androgen Receptor Specifically Interacts with a Novel p21-activated Kinase, PAK6, Journal of Biological Chemistry, vol.276, issue.18, pp.15345-15353, 2001.
DOI : 10.1074/jbc.M010311200

S. Lee, S. Ramos, A. Ko, D. Masiello, and K. Swanson, AR and ER Interaction with a p21-Activated Kinase (PAK6), Molecular Endocrinology, vol.16, issue.1, pp.85-99, 2002.
DOI : 10.1210/mend.16.1.0753

D. Soprano, B. Teets, and K. Soprano, Role of Retinoic Acid in the Differentiation of Embryonal Carcinoma and Embryonic Stem Cells, Vitam Horm, vol.75, pp.69-95, 2007.
DOI : 10.1016/S0083-6729(06)75003-8

J. Schoorlemmer, A. Vanpuijenbroek, M. Vandeneijnden, L. Jonk, and C. Pals, Characterization of a negative retinoic acid response element in the murine Oct4 promoter., Molecular and Cellular Biology, vol.14, issue.2, pp.1122-1136, 1994.
DOI : 10.1128/MCB.14.2.1122

C. Ross-innes, R. Stark, K. Holmes, D. Schmidt, and C. Spyrou, Cooperative interaction between retinoic acid receptor-?? and estrogen receptor in breast cancer, Genes & Development, vol.24, issue.2, pp.171-182, 2010.
DOI : 10.1101/gad.552910

C. Lin, A. Garrett, K. De, E. Smith, and M. Gogol, Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC), Genes & Development, vol.25, issue.14, pp.1486-1498, 2011.
DOI : 10.1101/gad.2059211

V. Bres, S. Yoh, and K. Jones, The multi-tasking P-TEFb complex, Current Opinion in Cell Biology, vol.20, issue.3, pp.334-340, 2008.
DOI : 10.1016/j.ceb.2008.04.008

L. May, N. Mota-fernandes, D. Velez-cruz, R. Iltis, I. Biard et al., NER Factors Are Recruited to Active Promoters and Facilitate Chromatin Modification for Transcription in the Absence of Exogenous Genotoxic Attack, Molecular Cell, vol.38, issue.1, pp.54-66, 2010.
DOI : 10.1016/j.molcel.2010.03.004

Q. Zhou, T. Li, and D. Price, RNA Polymerase II Elongation Control, Annual Review of Biochemistry, vol.81, issue.1, pp.119-143, 2012.
DOI : 10.1146/annurev-biochem-052610-095910
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273853

M. Mendoza-parra, M. Walia, M. Sankar, and H. Gronemeyer, Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics, Molecular Systems Biology, vol.34, issue.1, p.538, 2011.
DOI : 10.1186/gb-2008-9-9-r137

R. Slany, The molecular biology of mixed lineage leukemia, Haematologica, vol.94, issue.7, pp.984-993, 2009.
DOI : 10.3324/haematol.2008.002436

K. Glover-cutter, S. Larochelle, B. Erickson, C. Zhang, and K. Shokat, TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II, Molecular and Cellular Biology, vol.29, issue.20, pp.5455-5464, 2009.
DOI : 10.1128/MCB.00637-09

S. Mahony, E. Mazzoni, S. Mccuine, R. Young, and H. Wichterle, Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis, Genome Biology, vol.12, issue.1, p.2, 2011.
DOI : 10.1186/gb-2011-12-1-r2

B. Sobhian, N. Laguette, A. Yatim, M. Nakamura, and Y. Levy, HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP, Molecular Cell, vol.38, issue.3, pp.439-451, 2010.
DOI : 10.1016/j.molcel.2010.04.012
URL : https://hal.archives-ouvertes.fr/hal-00485594

R. Chen, M. Liu, H. Li, Y. Xue, and W. Ramey, PP2B and PP1?? cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling, Genes & Development, vol.22, issue.10, pp.1356-1368, 2008.
DOI : 10.1101/gad.1636008

M. Zhou, K. Huang, K. Jung, W. Cho, and Z. Klase, Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29, Journal of Virology, vol.83, issue.2, pp.1036-1044, 2009.
DOI : 10.1128/JVI.01316-08

N. He, M. Liu, J. Hsu, Y. Xue, and S. Chou, HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription, Molecular Cell, vol.38, issue.3, pp.428-438, 2010.
DOI : 10.1016/j.molcel.2010.04.013

K. Bartholomeeusen, Y. Xiang, K. Fujinaga, and B. Peterlin, Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein, Journal of Biological Chemistry, vol.287, issue.43, pp.36609-36625, 2012.
DOI : 10.1074/jbc.M112.410746

D. Hargreaves, T. Horng, and R. Medzhitov, Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation, Cell, vol.138, issue.1, pp.129-145, 2009.
DOI : 10.1016/j.cell.2009.05.047

S. Wu and C. Chiang, The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation, Journal of Biological Chemistry, vol.282, issue.18, pp.13141-13145, 2007.
DOI : 10.1074/jbc.R700001200

D. Lee, H. Duan, and C. Chang, Androgen Receptor Interacts with the Positive Elongation Factor P-TEFb and Enhances the Efficiency of Transcriptional Elongation, Journal of Biological Chemistry, vol.276, issue.13, pp.9978-9984, 2001.
DOI : 10.1074/jbc.M002285200

I. Iankova, R. Petersen, J. Annicotte, C. Chavey, and J. Hansen, Peroxisome Proliferator-Activated Receptor ?? Recruits the Positive Transcription Elongation Factor b Complex to Activate Transcription and Promote Adipogenesis, Molecular Endocrinology, vol.20, issue.7, pp.1494-1505, 2006.
DOI : 10.1210/me.2005-0222
URL : https://hal.archives-ouvertes.fr/inserm-00144653

B. Wittmann, K. Fujinaga, H. Deng, N. Ogba, and M. Montano, The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1, Oncogene, vol.63, issue.36, pp.5576-5588, 2005.
DOI : 10.1016/S1097-2765(03)00388-5

P. Rahl, C. Lin, A. Seila, R. Flynn, and S. Mccuine, c-Myc Regulates Transcriptional Pause Release, Cell, vol.141, issue.3, pp.432-445, 2010.
DOI : 10.1016/j.cell.2010.03.030
URL : http://doi.org/10.1016/j.cell.2010.03.030