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Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.

Guillaume Garcia 1, * Fabien Hammerer 1 Florent Poyer Sylvain Achelle 2 Marie-Paule Teulade-Fichou 1 Philippe Maillard 1
* Corresponding author
2 Organométalliques: Matériaux et Catalyse
CSVB - Conception, synthèse et vectorisation de biomolécules., ISCR - Institut des Sciences Chimiques de Rennes
Abstract : We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00878575
Contributor : Béatrice Mahi <>
Submitted on : Wednesday, October 30, 2013 - 12:18:37 PM
Last modification on : Tuesday, July 21, 2020 - 3:08:54 AM

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Guillaume Garcia, Fabien Hammerer, Florent Poyer, Sylvain Achelle, Marie-Paule Teulade-Fichou, et al.. Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.. Bioorganic and Medicinal Chemistry, Elsevier, 2013, 21 (1), pp.153-65. ⟨10.1016/j.bmc.2012.10.042⟩. ⟨hal-00878575⟩

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