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Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease.

Abstract : : The traditional management of CD, based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of CD and places patients at risk for bowel damage. The introduction of novel therapies and the development of new approaches to treatment in rheumatoid arthritis led to better outcomes for patients. Prominent among these is a "treat to target" strategy that is based on regular assessment of disease activity using objective clinical and biological outcome measures and the subsequent adjustment of treatments. This approach is complementary to the concept of early intervention in high risk patients. This review evaluates current literature on this topic and proposes a definition for the concept treating to targets for Crohn's disease.
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Contributor : Nathalie Coval <>
Submitted on : Friday, December 6, 2013 - 3:55:32 PM
Last modification on : Tuesday, October 13, 2020 - 10:47:01 AM

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Guillaume Bouguen, Barrett G. Levesque, Brian G. Feagan, Arthur Kavanaugh, Laurent Peyrin-Biroulet, et al.. Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease.. Clinical Gastroenterology and Hepatology, WB Saunders, 2013, 13 (6), pp.1042-1050.e2. ⟨10.1016/j.cgh.2013.09.006⟩. ⟨hal-00878688⟩

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