Mathematical modeling of respiratory system mechanics in the newborn lamb.

Virginie Le Rolle (1) , Nathalie Samson (2) , Jean-Paul Praud (2) , Alfredo I Hernández (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 UdeS - Département de pédiatrie [Sherbrooke]

In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental and simulated pressure and flow waveforms obtained during spontaneous ventilation and pleural pressure variations acquired during the application of positive pressure, since root mean square errors equal to 0.0119, 0.0052 and 0.0094. The identified parameters were discussed in light of previous knowledge of respiratory mechanics in the newborn.

Mots clés: Model; Animal experimentation; Sensitivity analysis; Parameter identification

Domaines: Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]; Ingénierie biomédicale

Virginie Le Rolle, Nathalie Samson, Jean-Paul Praud, Alfredo I Hernández. Mathematical modeling of respiratory system mechanics in the newborn lamb.. Acta Biotheoretica, 2013, 61 (1), pp.91-107. ⟨10.1007/s10441-013-9175-7⟩. ⟨hal-00880028⟩