Evaluation of T-wave Morphology Parameters in Drug-Induced Repolarization Abnormalities

Nadine Khodor (1) , Guy Carrault (1) , Hassan Amoud (2) , Mohamad Khalil (2) , Philippe L'Hostis (3) , Alfredo I. Hernandez (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 LU / ULB - الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth]
3 Biotrial

This study evaluates the predictive values of T-wave morphology parameters reflecting the repolarization changes by beat to beat calculation of parameters using different mathematical tools to identify additional markers sensitive to the variation induced by drug in the surface of the electrocardiogram. T-wave morphology indicators are extracted from nearly 6 hours recordings of two patients from a clinical d-Sotalol study. The results show that drug induced change in T-wave morphology as well as QT interval. In particular, parameters extracted from spherical coordinates of vectrocardiogram that were not tested before for drug effect evaluation show high sensitivity to small change induced by drugs.

Mots clés: ECG; ventricular repolarization; T-wave morphology; d-Sotalol

Domaines: Ingénierie biomédicale; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]

Nadine Khodor, Guy Carrault, Hassan Amoud, Mohamad Khalil, Philippe L'Hostis, et al.. Evaluation of T-wave Morphology Parameters in Drug-Induced Repolarization Abnormalities. 2nd International Conference on Advances in Biomedical Engineering (ICABME), Sep 2013, Tripoli, Lebanon. pp.203 - 206, ⟨10.1109/ICABME.2013.6648883⟩. ⟨hal-00881382⟩