Mouse whole-body organ mapping by non-rigid registration approach.

Di Xiao (1) , David Zahra , Pierrick Bourgeat (1) , Paula Berghofer , Oscar Acosta Tamayo , Heather Green , Marie Claude Gregoire , Olivier Salvado (1)

1 CSIRO ICT Centre - CSIRO Information and Commuciation Technologies

Automatic small animal whole-body organ registration is challenging because of subject's joint structure, posture and position difference and loss of reference features. In this paper, an improved 3D shape context based non-rigid registration method is applied for mouse whole-body skeleton registration and lung registration. A geodesic path based non-rigid registration method is proposed for mouse torso skin registration. Based on the above registration methods, a novel non-rigid registration framework is proposed for mouse whole-body organ mapping from an atlas to new scanned CT data. A preliminary experiment was performed to test the method on lung and skin registration. A whole-body organ mapping was performed on three target data and the selected organs were compared with the manual outlining results. The robust of the method has been demonstrated.

Domaines: Ingénierie biomédicale

Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, et al.. Mouse whole-body organ mapping by non-rigid registration approach.. Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, Feb 2011, Lake Buena Vista, Florida, United States. p., ⟨10.1117/12.877921⟩. ⟨hal-00908887⟩