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Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling

Denis Michel 1, * Philippe Ruelle 2, *
* Corresponding author
1 Trec - Transcription, environnement et cancer
Irset - Institut de recherche en santé, environnement et travail
Abstract : The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Seven methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.
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Submitted on : Thursday, December 19, 2013 - 11:19:10 AM
Last modification on : Thursday, November 28, 2019 - 12:08:10 PM
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Denis Michel, Philippe Ruelle. Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling. Journal of Mathematical Chemistry, Springer Verlag (Germany), 2013, 51 (9), pp.2271-2284. ⟨10.1007/s10910-013-0237-5⟩. ⟨hal-00920806v1⟩

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