MetAmyl: A METa-Predictor for AMYLoid Proteins - Université de Rennes Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2013

MetAmyl: A METa-Predictor for AMYLoid Proteins

Résumé

The aggregation of proteins or peptides in amyloid fibrils is associated with a number of clinical disorders, including Alzheimer's, Huntington's and prion diseases, medullary thyroid cancer, renal and cardiac amyloidosis. Despite extensive studies, the molecular mechanisms underlying the initiation of fibril formation remain largely unknown. Several lines of evidence revealed that short amino-acid segments (hot spots), located in amyloid precursor proteins act as seeds for fibril elongation. Therefore, hot spots are potential targets for diagnostic/therapeutic applications, and a current challenge in bioinformatics is the development of methods to accurately predict hot spots from protein sequences. In this paper, we combined existing methods into a meta-predictor for hot spots prediction, called MetAmyl for METapredictor for AMYLoid proteins. MetAmyl is based on a logistic regression model that aims at weighting predictions from a set of popular algorithms, statistically selected as being the most informative and complementary predictors. We evaluated the performances of MetAmyl through a large scale comparative study based on three independent datasets and thus demonstrated its ability to differentiate between amyloidogenic and non-amyloidogenic polypeptides. Compared to 9 other methods, MetAmyl provides significant improvement in prediction on studied datasets. We further show that MetAmyl is efficient to highlight the effect of point mutations involved in human amyloidosis, so we suggest this program should be a useful complementary tool for the diagnosis of these diseases.
Fichier principal
Vignette du fichier
journal.pone.0079722.pdf (273.58 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-00925855 , version 1 (08-01-2014)

Identifiants

Citer

Mathieu Emily, Anthony Talvas, Christian Delamarche. MetAmyl: A METa-Predictor for AMYLoid Proteins. PLoS ONE, 2013, 8 (11), pp.e79722. ⟨10.1371/journal.pone.0079722⟩. ⟨hal-00925855⟩
453 Consultations
319 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More