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Buffers Affect the Bending Rigidity of Model Lipid Membranes

Abstract : In biophysical and biochemical studies of lipid bilayers the influence of the used buffer is often ignored or assumed to be negligible on membrane structure, elasticity, or physical properties. However, we here present experimental evidence, through bending rigidity measurements performed on giant vesicles, of a more complex behavior, where the buffering molecules may considerably affect the bending rigidity of phosphatidylcholine bilayers. Furthermore, a synergistic effect on the bending modulus is observed in the presence of both salt and buffer molecules, which serves as a warning to experimentalists in the data interpretation of their studies, since typical lipid bilayer studies contain buffer and ion molecules.
Keywords : ELASTICITY HEPES
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00952387
Contributor : Morgane Le Corre <>
Submitted on : Wednesday, February 26, 2014 - 4:34:21 PM
Last modification on : Friday, August 23, 2019 - 3:20:03 PM

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Hélène Bouvrais, Lars Duelund, John H. Ipsen. Buffers Affect the Bending Rigidity of Model Lipid Membranes. Langmuir, American Chemical Society, 2013, 30 (1), pp.13-16. ⟨10.1021/la403565f⟩. ⟨hal-00952387⟩

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