Sensitivity Analysis and Parameter Estimation of a Coronary Circulation Model for Triple-Vessel Disease - Archive ouverte HAL Access content directly
Journal Articles IEEE Transactions on Biomedical Engineering Year : 2014

Sensitivity Analysis and Parameter Estimation of a Coronary Circulation Model for Triple-Vessel Disease

Abstract

Mathematical models of the coronary circulation have been shown to provide useful information for the analysis of intracoronary blood flow and pressure measurements acquired during coronary artery bypass graft (CABG) surgery. Although some efforts towards the patient-specific estimation of model parameters have been presented in this context, they are based on simplifying hypotheses about the collateral circulation and do not take advantage of the whole set of data acquired during CABG. In order to overcome these limitations, this paper presents an exhaustive parameter sensitivity analysis and a multiobjective patient-specific parameter estimation method, applied to a model of the coronary circulation of patients with triple vessel disease. The results of the sensitivity analysis highlighted the importance of capillary and collateral development. On the other hand, the estimation method was applied to intraoperative clinical data from ten patients obtained during CABG, which permitted to assess patient-specific collateral vessel situations. These approaches provide new insights regarding the heterogeneous configuration of the collateral circulation.
Fichier principal
Vignette du fichier
TBME-00791-2013.R2-accepted-version.pdf (722.79 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-00961247 , version 1 (19-03-2014)
hal-00961247 , version 2 (20-03-2014)

Identifiers

Cite

David Ojeda, Virginie Le Rolle, Majid Harmouche, Agnès Drochon, Hervé Corbineau, et al.. Sensitivity Analysis and Parameter Estimation of a Coronary Circulation Model for Triple-Vessel Disease. IEEE Transactions on Biomedical Engineering, 2014, 61 (4), pp.1208 - 1219. ⟨10.1109/TBME.2013.2296971⟩. ⟨hal-00961247v2⟩
167 View
314 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More