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Journal articles
Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.
Abstract : Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS.
Cited literature [11 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00974560
Contributor : Laurent Jonchère <>
Submitted on : Monday, April 23, 2018 - 11:06:59 AM
Last modification on : Wednesday, May 16, 2018 - 11:23:19 AM
Long-term archiving on: : Tuesday, September 18, 2018 - 6:33:25 PM
Contributor : Laurent Jonchère <>
Submitted on : Monday, April 23, 2018 - 11:06:59 AM
Last modification on : Wednesday, May 16, 2018 - 11:23:19 AM
Long-term archiving on: : Tuesday, September 18, 2018 - 6:33:25 PM
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Lemal - Large granular lymphoc...
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