Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.

Richard Lemal (1) , Carine Chaleteix (1) , Patrice Minard (2) , Corinne Roche (3) , Jacques-Olivier Bay (1) , Olivier Tournilhac (1) , Thierry Lamy (4, 5)

1 CIC 1405 - Centre d'Investigation Clinique [CHU Clermont-Ferrand]
2 Service d'Oncologie [Vichy]
3 Service de Neurologie [Vichy]
4 MiCa - Microenvironnement et cancer
5 Service d'hématologie clinique

Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS.

Keywords: Large granular lymphocytic leukemia; LGL leukemia; Lambert-Eaton Myasthenic Syndrome

Domains: Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Human health and pathology; Hematology

Richard Lemal, Carine Chaleteix, Patrice Minard, Corinne Roche, Jacques-Olivier Bay, et al.. Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.. Leukemia Research Reports, 2013, 2 (1), pp.32-33. ⟨10.1016/j.lrr.2013.02.004⟩. ⟨hal-00974560⟩