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Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.

Abstract : Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS.
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Richard Lemal, Carine Chaleteix, Patrice Minard, Corinne Roche, Jacques-Olivier Bay, et al.. Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.. Leukemia Research Reports, Elsevier, 2013, 2 (1), pp.32-33. ⟨10.1016/j.lrr.2013.02.004⟩. ⟨hal-00974560⟩

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