Skip to Main content Skip to Navigation
Journal articles

Identification of a novel Xenopus laevis poly (A) binding protein.

Abstract : Poly (A) binding proteins are intimately implicated in controlling a number of events in mRNA metabolism from nuclear polyadenylation to cytoplasmic translation and stability. The known poly(A) binding proteins can be divided into three distinct structural groups (prototypes PABP1, PABPN1/PABP2 and Nab2p) and two functional families, showing that similar functions can be accomplished by differing structural units. This has prompted us to perform a screen for novel poly(A) binding proteins using Xenopus laevis. A novel poly(A) binding protein of 32 kDa (p32) was identified. Sequence analysis showed that p32 has about 50% identity to the known nuclear poly(A) binding proteins (PABPN1) but is more closely related to a group of mammalian proteins of unknown function. The expression of Xenopus laevis ePABP2 is restricted to early embryos. Accordingly, we propose that p32 is the founder member of a novel class of poly(A) binding proteins named ePABP2.
Document type :
Journal articles
Complete list of metadata
Contributor : Luc Paillard Connect in order to contact the contributor
Submitted on : Thursday, April 24, 2014 - 11:27:29 AM
Last modification on : Wednesday, April 27, 2022 - 4:04:37 AM

Links full text



Bertrand Cosson, Frederique Braun, Luc Paillard, Perry Blackshear, H. Beverley Osborne. Identification of a novel Xenopus laevis poly (A) binding protein.. Biology of the Cell, Wiley, 2004, 96 (7), pp.519-27. ⟨10.1016/j.biolcel.2004.04.006⟩. ⟨hal-00982685⟩



Record views