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For the sake of clarity, only 860 the highest 5% signals are shown. Grey and red boxes delineate cell-specific ER binding sites (ERBSs) whilst 861 common ERBSs are in green. (D) Anti ER ChIP and FAIRE assays were conducted using chromatin prepared from 862 MCF-7, MDA-MB231 or MDA::ER cells treated with E2 or ethanol (EtOH) as vehicle control for 50 min. Results 863 shown within heatmaps are means from 6 to 9 values obtained in independent triplicate experiments. Values are 864 fold enrichments over control samples and a negative control region (promoter of the transcriptionally active Rplp0 865 gene). (E) Overlap of MDA::ER ERBSs with MCF-7 ones on regions spotted on the arrays. (F) Enrichment signals 866 obtained for anti-RNA Polymerase II (Pol II) ChIP-chip experiments performed, MDA::ER cells treated for 50 min 867 with E2 [MCF-7 data from (17)] were aligned on MCF-7 or MDA::ER ERBS identified within the regions spotted on 868 the arrays and located more than 10 Kbp away from the TSS of any ,