]. R. Wauchope, T. M. Buttler, A. G. Hornsby, P. W. Augustijn-beckers, J. P. Burt-]-r et al., The SCS/ARS/CES pesticide properties database for environmental decision-making Malathion deposition, metabolite clearance, and cholinesterase status of date dusters and harvesters in California Sultatos, Mammalian toxicology of organophosphorus pesticides Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms Potentiation of toxicity of organophosphorus compounds containing carboxylic ester functions toward warm-blooded animals by some organophosphorus impurities The toxicological properties of impurities in malathion, Rev Environ Contam Toxicol Arch Environ Contam Toxicol J Toxicol Environ Health Drug Metab Dispos J Agric Food Chem Arch Toxicol, vol.123, issue.422, pp.1-155, 1972.

R. E. Talcott, H. Denk, N. M. Mallipudi9-]-f, E. Buratti, and . Testai, Malathion carboxylesterase activity in human liver and its inactivation by isomalathion Malathion detoxification by human hepatic carboxylesterases and its inhibition by isomalathion and other pesticides Toxic effects of pesticide mixtures at a molecular level: their relevance to human health Genetic toxicity of malathion: a review, Epidemic malathion poisoning in Pakistan malaria workers, pp.31-34, 1978.

J. M. Pluth, J. A. Nicklas, J. P. O-'neill, R. J. Albertini, and M. T. Osorio, Increased frequency of specific genomic deletions resulting from in vitro malathion exposure, Cancer Res, vol.5613, issue.10, pp.2393-2399, 1996.

. Smith, Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: a study of malathion-exposed workers Clastogenic effect of pesticides in peripheral lymphocytes of cotton-field workers, Mutat Res Mutat Res, vol.38815, issue.2613, pp.85-95, 1991.

J. Blasiak, P. Jaloszynski, A. Trzeciak, and K. Szyfter, In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics, Mutation research Chem Biol Interact, vol.44517, issue.1681, pp.275-283, 1999.

. Guillouzo, Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells, Drug Metab Dispos, vol.34, issue.1, pp.75-83, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00702085

P. Gripon, S. Rumin, S. Urban, J. L. Seyec, D. Glaise et al., Infection of a human hepatoma cell line by hepatitis B virus, Proc Natl Acad Sci, issue.24, pp.99-15655, 2002.

A. Guguen-guillouzo and . Corlu, Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.4520, issue.4, pp.957-967, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00690471

A. Guillouzo and . Guillouzo, Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells, Toxicology and applied pharmacology, vol.24521, issue.2, pp.256-263, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00533754

R. Josse, A. Rogue, E. Lorge, and A. Guillouzo, An adaptation of the human HepaRG cells to the in vitro micronucleus assay Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B), Mutagenesis Arch Biochem Biophys, vol.2723, issue.3152, pp.295-304, 1994.

R. Josse, J. Dumont, A. Fautrel, M. A. Robin, and A. Guillouzo, Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds, Toxicology and Applied Pharmacology, vol.258, issue.2, pp.176-187, 2012.
DOI : 10.1016/j.taap.2011.10.019

URL : https://hal.archives-ouvertes.fr/hal-00866033

G. De-sousa, F. Fontaine, M. Pralavorio, D. Botta-fridlund, Y. Letreut et al., Insecticide cytotoxicity and CYP1A1/2 induction in primary human and rat hepatocyte cultures, Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG2) cells, pp.451-457, 1997.
DOI : 10.1016/S0887-2333(97)00061-1

R. Josse, C. Aninat, D. Glaise, J. Dumont, V. Fessard et al., Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies, Drug metabolism and disposition: the biological fate of chemicals Selected pesticide residues and metabolites in urine from a survey of the U.S. general population, J Toxicol Environ Health, vol.3628, issue.372, pp.1111-1118, 1992.

J. J. Pellizzari, A. Quackenboss, K. Roy, . F. Sexton29-]-v, R. L. Garry et al., Measurement of children's exposure to pesticides: analysis of urinary metabolite levels in a probability-based sample Preparation for human study of pesticide applicators: sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes exposed to selected fumigants Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate pesticides individually and in mixture, in rat tissues, Environ Health Perspect Teratog Carcinog Mutagen Environ Toxicol, vol.109, issue.101, pp.583-590, 1990.

. Hakkola, Characterization of human cytochrome P450 induction by pesticides, Toxicology, vol.294, issue.1, pp.17-26, 2012.