Cooperative interaction of benzo[a]pyrene and ethanol on plasma membrane remodeling is responsible for enhanced oxidative stress and cell death in primary rat hepatocytes.

Aurore Collin (1, 2) , Kevin Hardonnière (1, 2) , Martine Chevanne (1, 2) , Julie Vuillemin (1, 2) , Normand Podechard (1, 2) , Agnès Burel (2) , Marie-Thérèse Dimanche-Boitrel (1, 2) , Dominique Lagadic-Gossmann (1, 2) , Odile Sergent (3)

1 Irset - Institut de recherche en santé, environnement et travail
2 Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes
3 SMS - Stress, membrane et signalisation

Keywords: Benzo[a]pyrene; Ethanol; Liver; Primary rat hepatocytes; Oxidative stress; Lipid rafts; Membrane fluidity; Lysosome; Reactive oxygen species; Iron

Domains: Life Sciences [q-bio]

Aurore Collin, Kevin Hardonnière, Martine Chevanne, Julie Vuillemin, Normand Podechard, et al.. Cooperative interaction of benzo[a]pyrene and ethanol on plasma membrane remodeling is responsible for enhanced oxidative stress and cell death in primary rat hepatocytes.. Free Radical Biology and Medicine, 2014, 72, pp.11-22. ⟨10.1016/j.freeradbiomed.2014.03.029⟩. ⟨hal-01018147⟩