EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS, Drug Metabolism and Disposition, vol.34, issue.1, pp.75-83, 2006. ,
DOI : 10.1124/dmd.105.006759
URL : https://hal.archives-ouvertes.fr/hal-00702085
Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells, Drug Metabolism and Disposition, vol.38, issue.3, pp.516-525, 2010. ,
DOI : 10.1124/dmd.109.030197
URL : https://hal.archives-ouvertes.fr/hal-00741715
Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells, Hepatology, vol.96, issue.Suppl., pp.1895-1905, 2011. ,
DOI : 10.1002/hep.24290
URL : https://hal.archives-ouvertes.fr/hal-00739358
Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis, Journal of Hepatology, vol.47, issue.4, pp.565-570, 2007. ,
DOI : 10.1016/j.jhep.2007.04.013
PPAR??: a dagger in the heart of the metabolic syndrome, Journal of Clinical Investigation, vol.116, issue.3, pp.590-597, 2006. ,
DOI : 10.1172/JCI27955
A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis, New England Journal of Medicine, vol.355, issue.22, pp.2297-2307, 2006. ,
DOI : 10.1056/NEJMoa060326
Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the ??-Cell Line INS-1, Endocrinology, vol.150, issue.7, pp.3049-3057, 2009. ,
DOI : 10.1210/en.2008-0913
The Natural History of Non-Alcoholic Fatty Liver Disease, Digestive Diseases, vol.28, issue.1, pp.162-168, 2010. ,
DOI : 10.1159/000282081
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.103, issue.4, pp.957-967, 2007. ,
DOI : 10.1002/hep.21536
URL : https://hal.archives-ouvertes.fr/hal-00690471
Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-??/?? Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys, Endocrinology, vol.151, issue.7, pp.3115-3124, 2010. ,
DOI : 10.1210/en.2009-1366
Comparative Transcriptional Network Modeling of Three PPAR-??/?? Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes, PLoS ONE, vol.32, issue.4, p.35012, 2012. ,
DOI : 10.1371/journal.pone.0035012.g007
Transcriptional Regulation of Metabolism, Physiological Reviews, vol.86, issue.2, pp.465-514, 2006. ,
DOI : 10.1152/physrev.00025.2005
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease, Proceedings of the National Academy of Sciences, vol.106, issue.44, pp.18831-18836, 2009. ,
DOI : 10.1073/pnas.0909731106
Pharmacokinetics and metabolism of tesaglitazar, a novel dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist, after a single oral and intravenous dose in humans, Drug Metab Dispos, vol.32, pp.923-929, 2004. ,
Targeted Disruption of the Peroxisomal Fatty Acyl-CoA Oxidase Gene: Generation of a Mouse Model of Pseudoneonatal Adrenoleukodystrophy, Annals of the New York Academy of Sciences, vol.15, issue.1 Peroxisomes, pp.530-541, 1996. ,
DOI : 10.1074/jbc.271.44.27237
Metabolic effects of muraglitazar in type 2 diabetic subjects, Diabetes, Obesity and Metabolism, vol.347, issue.(Suppl 3), pp.893-902, 2011. ,
DOI : 10.1111/j.1463-1326.2011.01429.x
PPAR?? and PPAR?? dual agonists for the treatment of type 2 diabetes and the metabolic syndrome, Current Opinion in Pharmacology, vol.6, issue.6, pp.606-614, 2006. ,
DOI : 10.1016/j.coph.2006.06.009
Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo, Gastroenterology, vol.110, issue.1, pp.210-220, 1996. ,
DOI : 10.1053/gast.1996.v110.pm8536859
Liver Peroxisome Proliferator-activated Receptor ?? Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass, Journal of Biological Chemistry, vol.278, issue.36, pp.34268-34276, 2003. ,
DOI : 10.1074/jbc.M300043200
Nonalcoholic Fatty Liver Disease: Pathogenesis and Potential for Nuclear Receptors as Therapeutic Targets, Molecular Pharmaceutics, vol.5, issue.1, pp.49-59, 2008. ,
DOI : 10.1021/mp700110z
Nonlinear partial differential equations and applications: Infection of a human hepatoma cell line by hepatitis B virus, Proceedings of the National Academy of Sciences, vol.99, issue.24, pp.15655-15660, 2002. ,
DOI : 10.1073/pnas.232137699
Mechanistic modelling of tesaglitazar pharmacokinetic data in subjects with various degrees of renal function ??? evidence of interconversion, British Journal of Clinical Pharmacology, vol.6, issue.6, pp.855-863, 2008. ,
DOI : 10.1016/0163-7258(90)90036-2
Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPAR??, Gene, vol.380, issue.2, pp.84-94, 2006. ,
DOI : 10.1016/j.gene.2006.05.011
Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies, Drug Metabolism and Disposition, vol.36, issue.7, pp.1444-1452, 2008. ,
DOI : 10.1124/dmd.107.020016
ADD1/SREBP1 activates PPAR?? through the production of endogenous ligand, Proceedings of the National Academy of Sciences, vol.95, issue.8, pp.4333-4337, 1998. ,
DOI : 10.1073/pnas.95.8.4333
Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study, Hepatology, vol.23, issue.6, pp.1464-1467, 1996. ,
DOI : 10.1002/hep.510230624
PPAR?? ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR???/??? mice, European Journal of Pharmacology, vol.622, issue.1-3, pp.45-51, 2009. ,
DOI : 10.1016/j.ejphar.2009.09.002
Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches, Drugs, vol.53, issue.6, pp.1-14, 2013. ,
DOI : 10.1007/s40265-012-0004-0
The role of thiazolidinediones in non-alcoholic steatohepatitis ??? A systematic review and meta analysis, Journal of Hepatology, vol.55, issue.6, pp.1383-1390, 2011. ,
DOI : 10.1016/j.jhep.2011.03.016
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors, Pharmacological Reviews, vol.58, issue.4, pp.726-741, 2006. ,
DOI : 10.1124/pr.58.4.5
URL : https://hal.archives-ouvertes.fr/hal-00188041
Clinical Pharmacokinetics of Fibric Acid Derivatives (Fibrates), Clinical Pharmacokinetics, vol.34, issue.2, 1998. ,
DOI : 10.2165/00003088-199834020-00003
Role for PPAR?? in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts, The FASEB Journal, vol.25, issue.8, pp.2538-2550, 2011. ,
DOI : 10.1096/fj.10-173716
Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile, Chemico-Biological Interactions, vol.184, issue.3, pp.376-387, 2010. ,
DOI : 10.1016/j.cbi.2010.01.008
A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease, Hepatology, vol.51, issue.Supplement DDW, pp.79-104, 2010. ,
DOI : 10.1002/hep.23623
Amelioration of high fructose-induced metabolic derangements by activation of PPAR??, American Journal of Physiology - Endocrinology And Metabolism, vol.282, issue.5, pp.1180-1190, 2002. ,
DOI : 10.1152/ajpendo.00471.2001
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPAR?? agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet, European Journal of Pharmacology, vol.536, issue.1-2, pp.182-191, 2006. ,
DOI : 10.1016/j.ejphar.2006.02.028
Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial, Gastroenterology, vol.135, issue.1, pp.100-110, 2008. ,
DOI : 10.1053/j.gastro.2008.03.078
??: An Adaptive Metabolic System, Annual Review of Nutrition, vol.21, issue.1, pp.193-230, 2001. ,
DOI : 10.1146/annurev.nutr.21.1.193
Comparative gene expression profiles induced by PPARgamma and PPARalpha/gamma agonists in human hepatocytes, PLoS One, vol.6, 2011. ,
Efficacy and safety of muraglitazar: a double-blind, 24-week, dose-ranging study in patients with type 2 diabetes, Diabetes and Vascular Disease Research, vol.11, issue.3, pp.205-215, 2009. ,
DOI : 10.1177/1479164109336048
Pharmacokinetic Interactions with Thiazolidinediones, Clinical Pharmacokinetics, vol.63, issue.12, pp.1-12, 2007. ,
DOI : 10.2165/00003088-200746010-00001
Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity, The Journal of Lipid Research, vol.51, issue.5, pp.914-922, 2010. ,
DOI : 10.1194/jlr.M900251
The dual peroxisome proliferator???activated receptor ??/?? agonist tesaglitazar further improves the lipid profile in dyslipidemic subjects treated with atorvastatin, Metabolism, vol.56, issue.9, pp.1285-1292, 2007. ,
DOI : 10.1016/j.metabol.2007.05.003
Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR?? and RXR??, Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform, pp.696-708, 2010. ,
DOI : 10.1128/MCB.20.12.4436-4444.2000
Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection, Drug Metab Dispos, vol.34, pp.427-439, 2006. ,
Peroxisome-Proliferator-Activated Receptor ?? Activates Fat Metabolism to Prevent Obesity, Cell, vol.113, issue.2, pp.159-170, 2003. ,
DOI : 10.1016/S0092-8674(03)00269-1
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c, Journal of Clinical Investigation, vol.113, issue.10, pp.1408-1418, 2004. ,
DOI : 10.1172/JCI21025
Prior Thiazolidinedione Treatment Preserves Insulin Sensitivity in Normal Rats during Acute Fatty Acid Elevation: Role of the Liver, Endocrinology, vol.143, issue.12, pp.4527-4535, 2002. ,
DOI : 10.1210/en.2002-220387
Tesaglitazar ameliorates non-alcoholic fatty liver disease and atherosclerosis development in diabetic low-density lipoprotein receptor-deficient mice, Exp Ther Med, vol.4, pp.987-992, 2012. ,
Peroxisome proliferator-activated receptor-?? coactivator 1?? (PGC-1??) regulates triglyceride metabolism by activation of the nuclear receptor FXR, Genes & Development, vol.18, issue.2, pp.157-169, 2004. ,
DOI : 10.1101/gad.1138104