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Anisyl and ferrocenyl adducts of methylenepyran-containing β-diketone: Synthesis, spectral, structural, and redox properties

Abstract : Wittig reaction between the in situ generated [2,6-diphenyl-4H-pyran-4-yl phosphorane and methyl 4-formylbenzoate afforded the methyl 4-[(2,6-diphenyl-4H-pyran-4-ylidene)methyl]benzoate precursor 2 in 75% yield. The anisyl and ferrocenyl adducts of methylenepyran-containing β-diketones 3 and 4, respectively, were prepared from the base-catalyzed Claisen condensation reaction between precursor 2 and 4-methoxyacetophenone or acetylferrocene, using t-BuO−K+ as basic initiator. Both β-diketones 3 and 4 were isolated as an orange and dark-red crystalline solids in 50% yield, respectively. The acetyl derivative 6, 1-acetyl-1′-methylenepyranyl-ferrocene, was synthesized following a classical Friedel-Crafts acylation reaction of the parent ferrocenylmethylenepyran 5, and isolated in 61% yield as a red microcrystalline powder. The condensation reaction between the electron-rich acetyl complex 6 and acetyl acetate, using lithium diisopropylamide as the active base initiator, provided the ferrocenylmethylenepyran-containing β-diketone, 1-(1,3-dioxobutyl)-1′-[(2,6-diphenyl-4H-pyran-4-ylidene)methyl] ferrocene 7, isolated in 20% yield as an orange powder. The composition and identity of the new compounds 2-4, 6 and 7 are supported by elemental analysis, FT-IR, one- and two-dimensional 1H and 13C NMR spectral data and mass spectrometry. Additionally, the molecular structures of compounds 2, 4 and 6 were ascertained by single-crystal X-ray diffraction study. FT-IR and NMR spectral data indicate that both β-diketones 3 and 4 do solely exist as their keto-enol tautomeric form in solution and in the solid state, whereas a mixture of keto-enol and β-diketone tautomers in a 73:27 spectroscopic ratio was observed for 7. In the three cases, enolization takes place exclusively away from the anisyl or ferrocenyl group with formation of a six-membered pseudo-aromatic keto-enol ring, confirmed by the crystal structure of 4. Cyclic voltammetric measurements revealed that all the compounds undergo a single one-electron oxidation, localized presumably at the methylenepyran unit. This first oxidation generates a radical cation that undergoes an intermolecular C-C bond coupling to form the corresponding dimer. Anodically shifted to the first oxidation, cyclovoltammogram of 4 exhibits one reversible two-electron oxidation while that of 6 and 7 present two successive reversible one-electron oxidations, attributed in the three cases to the ferrocenyl fragment of the dimer.
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Submitted on : Tuesday, August 26, 2014 - 11:51:11 AM
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Néstor Novoa, Thierry Roisnel, Vincent Dorcet, Jean-René Hamon, David Carillo, et al.. Anisyl and ferrocenyl adducts of methylenepyran-containing β-diketone: Synthesis, spectral, structural, and redox properties. Journal of Organometallic Chemistry, Elsevier, 2014, 762, pp.19-28. ⟨10.1016/j.jorganchem.2014.03.029⟩. ⟨hal-01058192⟩



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