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Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy

Abstract : In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments has become of strategic importance. In the case of photodynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01059403
Contributor : Sylvain Achelle <>
Submitted on : Saturday, August 30, 2014 - 7:38:08 PM
Last modification on : Tuesday, September 22, 2020 - 3:57:38 AM

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Fabien Hammerer, Guillaume Garcia, Su Chen, Florent Poyer, Sylvain Achelle, et al.. Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy. Journal of Organic Chemistry, American Chemical Society, 2014, 79, pp.1406. ⟨10.1021/jo402658h⟩. ⟨hal-01059403⟩

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