Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy

Fabien Hammerer (1) , Guillaume Garcia (1) , Su Chen (1) , Florent Poyer , Sylvain Achelle (2) , Celine Fiorini Debuisschert (3) , Marie-Paule Teulade-Fichou (1) , Philippe Maillard (1)

1 CSVB - Conception, synthèse et vectorisation de biomolécules
2 ISCR - Institut des Sciences Chimiques de Rennes
3 LITEN - Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux

In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments has become of strategic importance. In the case of photodynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.

Domaines: Chimie organique; Chimie thérapeutique

Fabien Hammerer, Guillaume Garcia, Su Chen, Florent Poyer, Sylvain Achelle, et al.. Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy. Journal of Organic Chemistry, 2014, 79, pp.1406. ⟨10.1021/jo402658h⟩. ⟨hal-01059403⟩