Skip to Main content Skip to Navigation
Journal articles

The CD95/CD95L signaling pathway: A role in carcinogenesis.

Amélie Fouqué 1 Laure Debure 1 Patrick Legembre 1, *
* Corresponding author
1 Death Receptors and Tumor Escape
Irset - Institut de recherche en santé, environnement et travail, CRLCC - CRLCC Eugène Marquis
Abstract : Apoptosis is a fundamental process that contributes to tissue homeostasis, immune responses, and development. The receptor CD95, also called Fas, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance, and various lineages of malignant cells exhibit loss-of-function mutations in this pathway; therefore, CD95 was initially classified as a tumor suppressor gene. However, more recent data indicate that in different pathophysiological contexts, this receptor can transmit non-apoptotic signals, promote inflammation, and contribute to carcinogenesis. A comparison with the initial molecular events of the TNF-R signaling pathway leading to non-apoptotic, apoptotic, and necrotic pathways reveals that CD95 is probably using different molecular mechanisms to transmit its non-apoptotic signals (NF-κB, MAPK, and PI3K). As discussed in this review, the molecular process by which the receptor switches from an apoptotic function to an inflammatory role is unknown. More importantly, the biological functions of these signals remain elusive.
Document type :
Journal articles
Complete list of metadatas

Cited literature [177 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061290
Contributor : Laurent Jonchère <>
Submitted on : Friday, September 5, 2014 - 2:37:43 PM
Last modification on : Friday, November 29, 2019 - 1:47:39 AM
Long-term archiving on: : Saturday, December 6, 2014 - 11:40:31 AM

Files

BBAreviewsoncancer-legembre-fi...
Files produced by the author(s)

Identifiers

Citation

Amélie Fouqué, Laure Debure, Patrick Legembre. The CD95/CD95L signaling pathway: A role in carcinogenesis.. BBA - Biochimica et Biophysica Acta, Elsevier, 2014, 1846 (1), pp.130-141. ⟨10.1016/j.bbcan.2014.04.007⟩. ⟨hal-01061290⟩

Share

Metrics

Record views

645

Files downloads

758