Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.

Bernard Fromenty (1)

1 Foie, métabolismes et cancer

Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.

Keywords: Oxidative phosphorylation; Mitochondria; Uncoupling; Dinitrophenol; Fatty liver; Steatosis; Triacylglycerol

Domains: Life Sciences [q-bio]; Human health and pathology; Hépatology and Gastroenterology

Bernard Fromenty. Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.. Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (5), pp.545-549. ⟨10.1016/j.clinre.2014.04.013⟩. ⟨hal-01068679⟩