B. Cannon and J. Nedergaard, Brown Adipose Tissue: Function and Physiological Significance, Physiological Reviews, vol.84, issue.1, pp.277-359, 2004.
DOI : 10.1152/physrev.00015.2003

J. Dark, Annual lipid cycles in hibernators: integration of physiology and behavior, Annu Rev Nutr, vol.25, pp.469-97, 2005.

K. Rousseau, Z. Atcha, and A. Loudon, Leptin and Seasonal Mammals, Journal of Neuroendocrinology, vol.281, issue.4, pp.409-423, 2003.
DOI : 10.1046/j.1365-2826.2003.01007.x

S. Blumenthal, R. Morgan-boyd, and R. Nelson, Seasonal regulation of the growth hormone-insulin-like growth factor-I axis in the American black bear (Ursus americanus), AJP: Endocrinology and Metabolism, vol.301, issue.4
DOI : 10.1152/ajpendo.00082.2011

B. Fromenty, C. Fisch, and A. Berson, Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II, J Pharmacol Exp Ther, vol.255, pp.1377-84, 1990.

B. Sibille, C. Filippi, and M. Piquet, The mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous substrate, Biochemical Journal, vol.355, issue.1, pp.231-236, 2001.
DOI : 10.1042/bj3550231

URL : https://hal.archives-ouvertes.fr/inserm-00390018

B. Fromenty, P. Letteron, and C. Fisch, Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria, Biochemical Pharmacology, vol.46, issue.3, pp.421-453, 1993.
DOI : 10.1016/0006-2952(93)90518-2

X. Sun and K. Garlid, On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes, J Biol Chem, vol.267, pp.19147-54, 1992.

I. Larosche, P. Lettéron, and B. Fromenty, Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver, Journal of Pharmacology and Experimental Therapeutics, vol.321, issue.2, pp.526-561, 2007.
DOI : 10.1124/jpet.106.114546

K. Begriche, J. Massart, and M. Robin, Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver, Journal of Hepatology, vol.54, issue.4, pp.773-94, 2011.
DOI : 10.1016/j.jhep.2010.11.006

URL : https://hal.archives-ouvertes.fr/hal-00739371

A. Berson, S. Renault, and P. Lettéron, Uncoupling of rat and human mitochondria: A possible explanation for tacrine-induced liver dysfunction, Gastroenterology, vol.110, issue.6, pp.1878-90, 1996.
DOI : 10.1053/gast.1996.v110.pm8964414

M. Porceddu, N. Buron, and C. Roussel, Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria, Toxicological Sciences, vol.129, issue.2, pp.332-377, 2012.
DOI : 10.1093/toxsci/KFS197

URL : https://hal.archives-ouvertes.fr/hal-00866136

K. Begriche, A. Igoudjil, and D. Pessayre, Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it, Mitochondrion, vol.6, issue.1, pp.1-28, 2006.
DOI : 10.1016/j.mito.2005.10.004

W. Tomeno, M. Yoneda, and K. Imajo, Emerging drugs for non-alcoholic steatohepatitis, Expert Opinion on Emerging Drugs, vol.53, issue.2, pp.279-90, 2013.
DOI : 10.1016/j.cgh.2008.11.005

B. Viollet, B. Guigas, and J. Leclerc, AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives, Acta Physiologica, vol.108, issue.Pt 1, pp.81-98, 2009.
DOI : 10.1111/j.1748-1716.2009.01970.x

URL : https://hal.archives-ouvertes.fr/inserm-00363222

B. Cariou, R. Hanf, and S. Lambert-porcheron, Dual Peroxisome Proliferator-Activated Receptor ??/?? Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects, Diabetes Care, vol.36, issue.10, pp.2923-2953, 2013.
DOI : 10.2337/dc12-2012

B. Staels, A. Rubenstrunk, and B. Noel, Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, Hepatology, vol.57, issue.6, pp.1941-52, 2013.
DOI : 10.1093/eurheartj/ehs227

V. Samuel, Z. Liu, and X. Qu, Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease, Journal of Biological Chemistry, vol.279, issue.31, pp.32345-53, 2004.
DOI : 10.1074/jbc.M313478200

R. Perry, T. Kim, and X. Zhang, Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler, Cell Metabolism, vol.18, issue.5, pp.740-748, 2013.
DOI : 10.1016/j.cmet.2013.10.004

J. Parascandola, Dinitrophenol and bioenergetics: An historical perspective, Molecular and Cellular Biochemistry, vol.173, issue.1-2, pp.69-77, 1974.
DOI : 10.1007/BF01874175

J. Grundlingh, P. Dargan, and M. El-zanfaly, 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death, Journal of Medical Toxicology, vol.125, issue.5, pp.205-217, 2011.
DOI : 10.1007/s13181-011-0162-6

T. Szkudelski, Streptozotocin???nicotinamide-induced diabetes in the rat. Characteristics of the experimental model, Experimental Biology and Medicine, vol.38, issue.5, pp.481-90, 2012.
DOI : 10.1016/j.cmet.2007.09.003

K. Begriche, J. Massart, and B. Fromenty, Effects of ??-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity, Fundamental & Clinical Pharmacology, vol.283, issue.Suppl, pp.269-82, 2010.
DOI : 10.1111/j.1472-8206.2009.00765.x

URL : https://hal.archives-ouvertes.fr/hal-00741751

J. Laurin, K. Lindor, and J. Crippin, Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study, Hepatology, vol.23, issue.6, pp.1464-1471, 1996.
DOI : 10.1002/hep.510230624

W. Nseir, J. Mograbi, and M. Ghali, Lipid-Lowering Agents in Nonalcoholic Fatty Liver Disease and Steatohepatitis: Human Studies, Digestive Diseases and Sciences, vol.5, issue.7, pp.1773-81, 2012.
DOI : 10.1007/s10620-012-2118-3

T. Yoneshiro, S. Aita, and M. Matsushita, Recruited brown adipose tissue as an antiobesity agent in humans, Journal of Clinical Investigation, vol.123, issue.8, pp.3404-3412, 2013.
DOI : 10.1172/JCI67803DS1

A. Bartelt and J. Heeren, Adipose tissue browning and metabolic health, Nature Reviews Endocrinology, vol.13, issue.1, pp.24-36, 2014.
DOI : 10.1038/nrendo.2013.204

E. Tahara, F. Navarete, and A. Kowaltowski, Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation, Free Radical Biology and Medicine, vol.46, issue.9, pp.1283-97, 2009.
DOI : 10.1016/j.freeradbiomed.2009.02.008

P. Schönfeld, M. Wieckowski, and M. Lebiedzi?ska, Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1797, pp.929-967, 2010.
DOI : 10.1016/j.bbabio.2010.04.183

E. Seifert, C. Estey, and J. Xuan, Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2 Emission during Long-chain Fatty Acid Oxidation, Journal of Biological Chemistry, vol.285, issue.8, pp.5748-58, 2010.
DOI : 10.1074/jbc.M109.026203

P. Schönfeld and L. Wojtczak, Brown adipose tissue mitochondria oxidizing fatty acids generate high levels of reactive oxygen species irrespective of the uncoupling protein-1 activity state, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1817, issue.3, pp.410-418, 2012.
DOI : 10.1016/j.bbabio.2011.12.009

K. Begriche, J. Massart, and M. Robin, Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease, Hepatology, vol.6, issue.4, pp.1497-507, 2013.
DOI : 10.1002/hep.26226

URL : https://hal.archives-ouvertes.fr/inserm-00814080

S. Mantena, A. King, and K. Andringa, Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases, Free Radical Biology and Medicine, vol.44, issue.7, pp.1259-72, 2008.
DOI : 10.1016/j.freeradbiomed.2007.12.029

P. Porubsky, K. Meneely, and E. Scott, Structures of Human Cytochrome P-450 2E1: INSIGHTS INTO THE BINDING OF INHIBITORS AND BOTH SMALL MOLECULAR WEIGHT AND FATTY ACID SUBSTRATES, Journal of Biological Chemistry, vol.283, issue.48, pp.33698-707, 2008.
DOI : 10.1074/jbc.M805999200

L. Leung, A. Kalgutkar, and R. Obach, Metabolic activation in drug-induced liver injury, Drug Metabolism Reviews, vol.232, issue.6, pp.18-33, 2012.
DOI : 10.1021/tx700132x

J. Aubert, K. Begriche, and L. Knockaert, Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role, Clinics and Research in Hepatology and Gastroenterology, vol.35, issue.10, pp.630-637, 2011.
DOI : 10.1016/j.clinre.2011.04.015

URL : https://hal.archives-ouvertes.fr/hal-00739365

E. Takahara, S. Ohta, and M. Hirobe, Effect of oxygen concentration on the metabolic pathway of anisole in rat liver microsomes, Biochemical Pharmacology, vol.35, issue.3, pp.541-545, 1986.
DOI : 10.1016/0006-2952(86)90234-0

P. Wiebkin, G. Parker, and J. Fry, Effect of various metabolic inhibitors on biphenyl metabolism in isolated rat hepatocytes, Biochemical Pharmacology, vol.28, issue.22, pp.3315-3336, 1979.
DOI : 10.1016/0006-2952(79)90127-8

B. Stuart, J. Lloyd, and L. Zhao, Obesity, disease burden, and prescription spending by community-dwelling Medicare beneficiaries, Current Medical Research and Opinion, vol.24, issue.8, pp.2377-87, 2008.
DOI : 10.1185/03007990802262275

D. Juurlink, M. Mamdani, and A. Kopp, Drug-Drug Interactions Among Elderly Patients Hospitalized for Drug Toxicity, JAMA, vol.289, issue.13, pp.1652-1660, 2003.
DOI : 10.1001/jama.289.13.1652

B. Fromenty, Drug-induced liver injury in obesity, Journal of Hepatology, vol.58, issue.4, pp.824-830, 2013.
DOI : 10.1016/j.jhep.2012.12.018

URL : https://hal.archives-ouvertes.fr/hal-00865967

K. Yoshinari, T. Sato, and N. Okino, Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue, Journal of Pharmacology and Experimental Therapeutics, vol.311, issue.1, pp.147-54, 2004.
DOI : 10.1124/jpet.104.067066

K. Yoshinari, N. Okino, and T. Sato, INDUCTION OF DETOXIFYING ENZYMES IN RODENT WHITE ADIPOSE TISSUE BY ARYL HYDROCARBON RECEPTOR AGONISTS AND ANTIOXIDANTS, Drug Metabolism and Disposition, vol.34, issue.7, pp.1081-1090, 2006.
DOI : 10.1124/dmd.105.007286

S. Ellero, G. Chakhtoura, and C. Barreau, Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction, Drug Metabolism and Disposition, vol.38, issue.4, pp.679-86, 2010.
DOI : 10.1124/dmd.109.029249

URL : https://hal.archives-ouvertes.fr/hal-00466852

G. Michelotti, M. Machado, A. Diehl, . Nafld, L. Nash et al., NAFLD, NASH and liver cancer, Nature Reviews Gastroenterology & Hepatology, vol.16, issue.11, pp.656-65, 2013.
DOI : 10.6061/clinics/2013(03)OA02

A. Lade, L. Noon, and S. Friedman, Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer, Current Opinion in Oncology, vol.26, issue.1, pp.100-107, 2014.
DOI : 10.1097/CCO.0000000000000042