Benzyl β-malolactonate polymers: a long story with recent advances

Cédric C. Jaffredo (1) , Sophie M. Guillaume (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

Poly (-benzyl malolactonate) (PMLABe) is an aliphatic renewable, biocompatible, biodegradable, hydrophobic polyester of the poly(hydroxyalkanoate) (PHA) family. Along with the hydrophilic parent poly(-malic acid) (PMLA), PMLABe and PMLA have been studied as materials for biomedical applications. Herein, advances on the synthesis of benzyl -malolactonate (MLABe) and the related alkyl -malolactonates (MLARs), PMLABe homopolymers and copolymers, are reviewed. Focus is placed on the ring-opening polymerization (ROP) of MLABe and on copolymers of MLABe, with relevant data on the performances of the initiating systems and on the PMLABes molecular characteristics, along with detailed mechanistic insights, being reported.

Keywords: Benzyl malolactonate; Poly(benzyl malolactonate); Poly(malic acid); Monomer and (co)polymers synthesis; Ring-opening polymerization

Domains: Chemical Sciences; Material chemistry

Cédric C. Jaffredo, Sophie M. Guillaume. Benzyl β-malolactonate polymers: a long story with recent advances. Polymer Chemistry, 2014, 5, pp.4168-4194. ⟨10.1039/c4py00170b⟩. ⟨hal-01077996⟩